Selective turnover of the essential fatty acid ester components of estradiol-17β lipoidal derivatives formed by human mammary cancer cells in culture
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Cited by (28)
Effect of clofibrate administration on the esterification and deesterification of steroid hormones by liver and extrahepatic tissues in rats
2002, Biochemical PharmacologyCitation Excerpt :In the present study, we found that Δ5-3β-hydroxysteroid acyltransferase activity (towards pregnenolone and dehydroepiandrosterone) in rat liver microsomes was comparable to the acyl-CoA:estradiol acyltransferase activity, and both enzyme activities were induced markedly by clofibrate administration (Table 1). An earlier study showed that pregnenolone and dehydroepiandrosterone competitively inhibit the esterification of estradiol [8]. These results suggest that the liver microsomal acyl-CoA acyltransferase that catalyzes the esterification of estradiol at the nonphenolic 17-hydroxyl group may be the same enzyme that catalyzes the esterification of pregnenolone and dehydroepiandrosterone at the nonphenolic 3-hydroxyl group.
Metabolism of lipoidal derivatives of estradiol-17β in human mammary cancer tissue and cell lines
1991, Journal of Steroid Biochemistry and Molecular BiologyEffect of estradiol and progesterone on long chain fatty acyl-coenzyme A levels in the rat uterus
1991, BBA - Molecular Cell ResearchMultiple steroid metabolic pathways in ZR-75-1 human breast cancer cells
1991, Journal of Steroid Biochemistry and Molecular BiologySteroidal fatty acid esters
1991, Journal of Steroid Biochemistry and Molecular Biology
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