Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG)

doi:10.1016/0022-4731(87)90200-7

Journal of Steroid Biochemistry

Volume 27, Issues 4–6, 1987, Pages 1135-1144

https://doi.org/10.1016/0022-4731(87)90200-7 Get rights and content

Abstract

A brief account of our present knowledge on the enterohepatic metabolism of estrogens and on the origin, metabolism and biological effects of mammalian lignans and phytoestrogens is undertaken. Furthermore, recently published results on the effects of dietary fiber, fat and carbohydrates on estrogen metabolism are reviewed. New preliminary results are presented on quantitative assays of lignans and phytoestrogens in urine of women belonging to various dietary and population groups and in a group of chimpanzees. The highest values of lignans and phytoestrogens were found in the non-human primates, and in macrobiotic, lactovegetarian and Japanese women, all groups considered having a low risk for the development of breast and other hormone-dependent cancer. New results on correlations between intake of various fibers, lignan and phytoestrogen excretion and plasma levels of estrogens, free testosterone and SHBG in women are presented. There is a significant positive correlation between the intake of fiber and urinary excretion of lignans and phytoestrogens, and the concentration of plasma SHBG. Fiber intake and urinary excretion of lignans and equol correlated negatively with plasma percentage free estradiol. Enterolactone excretion correlated negatively with plasma free testosterone. It is concluded that dietary macro- and micronutrients seem to play an important role in estrogen metabolism.

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Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG)

Abstract

J. steroid Biochem.

J. steroid Biochem.

J. steroid Biochem.

J. steroid Biochem.

Contraception

Am. J. obstet. Gynec.

J. steroid Biochem.

Am. J. clin. Nutr.

J. steroid Biochem.

J. steroid Biochem.

Clin. chim. Acta

Lancet

Clin. chim. Acta

J. steroid Biochem.

Lancet

FEBS Lett.

Steroids

Br. J. obstet. Gynaec.

Metabolism of androgens and estrogens by human fecal micro-organisms

J. steroid Biochem.

Oestrogen excretion in human bile

Acta endocr., Copenh. Suppl.

Effect of ampicillin administration on the excretion of twelve oestrogens in pregnancy urine

Acta endocr., Copenh.

Intestinal metabolism of estrogens

J. clin. endocr. Metab.

Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women

New Engl. J. Med.

Effect of diet and Lactobacillus acidophilus supplements on human fecal bacterial enzymes

J. natn. Cancer Inst.

The influence of dietary protein and carbohydrate on the principal oxidative biotransformations of estradiol in normal subjects

J. clin. Endocr. Metab.

Nutrition-endocrine interactions: induction of reciprocal changes in the Δ1-5α-reduction of testosterone and the cytochrome P-450-dependent oxidation of estradiol by dietary macronutritients in man

Nutrition-endocrine interactions: induction of reciprocal changes in the Δ¹-5α-reduction of testosterone and the cytochrome P-450-dependent oxidation of estradiol by dietary macronutritients in man