Pregnanolones, pregnenolone and progesterone in the human fetal tissues of early and midtrimester pregnancy
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2016, TheriogenologyPreliminary evidence of altered steroidogenesis in women with Alzheimer's disease: Have the patients "OLDER" adrenal zona reticularis?
2016, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :The de novo pregnenolone brain synthesis is indicated by strikingly higher pregnenolone levels in brain when compared to the circulating levels [12–16]. Furthermore, non-pregnant subjects [17] and fetuses have comparable pregnenolone levels in brain [18] but fetuses have exceedingly elevated circulating pregnenolone levels when compared to non-pregnant subjects [17]. Due to the lipophilic nature of steroids their concentrations in brain tissues (containing high amounts of lipophilic substances) are commonly several times higher in comparison with their concentrations in circulation and cerebrospinal fluid [14].
Steroid profiling in pregnancy: A focus on the human fetus
2014, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :5α/β-Reduced pregnane steroids are also present in high concentrations in various fetal tissues. For instance, the levels of unconjugated pregnanolone isomers in fetal tissues displayed as mean (maximum) are as follows (pmol/g): Allopregnanolone: brain 35 (60), placenta 53 (41), skin 69 (116), lung 82 (151), liver 9 (19), kidney 75 (321), intestine 85 (145), myometrium 30 (89); Isopregnanolone: brain 211 (494), placenta 186 (308), skin 50 (126), lung 362 (1009), liver 107 (528), kidney 368 (1321), intestine 148 (434), myometrium 63 (220); Pregnanolone: brain 50 (170), placenta 25 (53), skin 0 (0), lung 3 (6), liver 412 (824), kidney 129 (214), intestine 314 (594), myometrium 31 (92) [16–18]. Fetal liver converts the progesterone to its 5α/β-reduced metabolites while placenta converts the progesterone to the 5α-reduced ones only.
Neurosteroids exhibit differential effects on mIPSCs recorded from normal and seizure prone rats
2005, Journal of NeurophysiologyPartial agonism by 3α,21-dihydroxy-5β-pregnan-20-one at the γ- aminobutyric acid(A) receptor neurosteroid site
1997, Journal of Pharmacology and Experimental TherapeuticsEvidence that GABA(A) receptor subunit mRNA expression during development is regulated by GABA(A) receptor stimulation
1997, Journal of Neurochemistry