Elsevier

Journal of Molecular and Cellular Cardiology

Volume 8, Issue 3, March 1976, Pages 217-220, IN11-IN12, 221-238
Journal of Molecular and Cellular Cardiology

Arrhythmic movements of myocardial cells in culture and their improvement with antiarrhythmic drugs

https://doi.org/10.1016/0022-2828(76)90038-9Get rights and content

Abstract

Various types of arrhythmic movements of single isolated myocardial cells and clusters of these cells were observed on incubation in medium containing ouabain, or of low potassium or high calcium concentration. The percentage of single isolated cells which exhibited arrhythmic movements increased with increase in ouabain concentration, or calcium concentration, or decrease in potassium concentration. Under conditions causing increase in the percentage of arrhythmic single cells, the arrhythmic movements of cell clusters became more severe. The arrhythmic movements of both single isolated cells and cell clusters were improved by addition of antiarrhythmic drugs, such as quinidine or procaine amide. The genesis and improvement of arrhythmic movements of cell clusters were explained as due in part to the genesis and improvement of arrhythmic movements of the component cells in the clusters.

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