Liquid chromatography
Diastereomeric β-lactam antibiotics analytical methods, isomerization and stereoselective pharmacokinetics

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Abstract

Stereospecific HPLC methods for the determination of various diastereomeric β-lactam antibiotics are reviewed. Stereoselectivity in the absorption, distribution and excretion of several diastereomeric β-lactams is summarized. The isomerization of β-lactam isomers and its influence on the pharmacokinetics and pharmacodynamics are discussed.

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