Research paperInhibitors of angiotensin converting enzyme decrease early atherosclerosis in hyperlipidemic hamsters. Fosinopril reduces plasma cholesterol and captopril inhibits macrophage—foam cell accumulation independently of blood pressure and plasma lipids
References (62)
- et al.
A general cardiovascular risk profile: the Framingham study
Am. J. Cardiol.
(1976) - et al.
The effects of drug treatment for hypertension on morbidity and mortality from cardiovascular disease: a review of randomized controlled trials
Prog. Cardiovasc. Dis.
(1986) - et al.
Blood pressure, stroke, coronary heart disease. Part 2, short-term reductions in blood pressure: overview of randomized drug trials in their epidemiological context
Lancet
(1990) - et al.
Retardation of angiographic progression of coronary artery disease by nifedipine. Results of the international nifedipine trial on antiatherosclerotic therapy (INTACT)
Lancet
(1990) - et al.
Isolation, purification and characterization of a lipoprotein containing Apo B from the human aorta
Atherosclerosis
(1982) - et al.
A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein
J. Biol. Chem.
(1992) - et al.
Phospholipase AZ-modified LDL is taken up at enhanced rate by macrophages
Biochem. Biophys. Res. Commun.
(1992) - et al.
The effects of propranolol on cholesterol-induced atheromatous lesions
Atherosclerosis
(1973) - et al.
Verapamil suppresses atherosclerosis in cholesterol-fed rabbits
J. Am. Coll. Cardiol.
(1983) - et al.
Doxazosin and cholestyramine similarly decrease fatty streak formation in the aortic arch of hyperlipidemic hamsters
Atherosclerosis
(1991)
The hyperlipidemic hamster as a model of experimental atherosclerosis
Atherosclerosis
Renin synthesis by canine aortic smooth muscle cells in culture
Life Sci.
Localization of angiotensin converting enzyme (kininase II). II. Immunocytochemistry and immunofluorescence
Tissue Cell
The preferential human mononuclear leukocyte chemotactic activity of the substituent tetrapep tides of angiotensin II
Biochem. Biophys. Res. Commun.
Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: final report of the pooling project
J. Chron. Dis.
Atherosclerosis in persons with hypertension and diabetes mellitus
Lab. Invest.
Stenoses in the coronary arteries. Relation to atherosclerotic lesions, coronary heart disease and risk factors. The Oslo study
Lab. Invest.
A controlled clinical trial to assess the effect of a calcium channel blocker on the progression of coronary atherosclerosis
Circulation
Prelesional events of atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit
Am. J. Pathol.
Localization of unesterified cholesterol in human atherosclerotic lesions. Demonstration of filipin-positive, oil-red-O-negative particles
Am. J. Pathol.
The morphology of early atherosclerostic lesions of the aorta demonstrated by the surface technique in rabbits fed cho lesterol together with a description of the anatomy of the intima of the rabbit's aorta and the “spontaneous” lesions that occur in it
Am. J. Pathol.
Dietary induced atherogenesis in swine. Morphology of the intima in prelesion stages
Am. J. Pathol.
Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats
Am. J. Pathol.
Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity
N. Eng. J. Med.
Insoluble low-density lipoprotein-proteoglycan complexes enhance cholesteryl ester accumulation in macrophages
Am. J. Pathol.
Enhanced macrophage uptake of low density lipoprotein after self-aggregation
Arteriosclerosis
Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation. Sequential morphological and biochemical events
Arteriosclerosis Thromb.
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation
Arteriosclerosis
Fatty streak expansion and maturation in Watanabe Heritable Hyperlipidemic and comparably hypercholesterolemic fat-fed rabbits
Arteriosclerosis
Identification of macrophages and smooth muscle cells in human atherosclerosis using monoclonal antibodies
J. Pathol.
Atherogenesis during low level hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque
Arteriosclerosis
Cited by (98)
Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease
2021, Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and DiseasePharmacodynamic study of the cardiovascular polypill. Is there any interaction among the monocomponents?
2021, Revista Espanola de CardiologiaThe renin-angiotensin system and its involvement in vascular disease
2015, European Journal of PharmacologyCitation Excerpt :Because of the reported deleterious effects of Ang II on cardiovascular tissue, it seems logical to target the RAS and thereby reduce the development of cardiovascular damage. Several studies already demonstrated that ACE inhibitors might inhibit atherosclerosis in animal models independent of blood pressure lowering (Charpiot et al., 1993; Hayek et al., 1999; Kowala et al., 1994). Additionally, renin inhibition and angiotensin receptor blockers reduced atherosclerotic lesion size in cholesterol fed mice susceptible for atherosclerosis (Daugherty et al., 2004; Lu et al., 2007, 2008; Nussberger et al., 2008).
Angiotensin converting enzyme (ACE) inhibitory, antihypertensive and antihyperlipidaemic activities of protein hydrolysates from Rhopilema esculentum
2012, Food ChemistryCitation Excerpt :Epidemiological and experimental studies have shown that ACE inhibitors had a beneficial effect in early atherosclerosis in addition to their antihypertensive activity (Chobanian, Haudenschild, Nickerson, & Drago, 1990; Fennessy, Campbell, & Campbell, 1994). Pharmacological studies have also demonstrated that ACE inhibitors could reduce plasma cholesterol in different animal models (Kowala, Grove, & Aberg, 1994; Sugano, Makino, & Yanaga, 1996). More recent studies have reported that protein hydrolysates from several food materials, such as sardinelle (Khaled et al., 2012), fish (Wergedahl, Gudbrandsen, Røst, & Berge, 2009), sesame (Biswas, Dhar, & Ghosh, 2010) and soy (Aoyama, Fukui, Takamatsu, Hashimoto, & Yamamoto, 2000; Zhong, Zhang, Ma, & Shoemaker, 2007) could affect plasma cholesterol concentrations and metabolisms of polyunsaturated fatty acids.
Vascular wall ACE is not required for atherogenesis in ApoE<sup>-/-</sup> mice
2010, AtherosclerosisCitation Excerpt :It is well established that the renin angiotensin system is critically involved in the pathogenesis of atherosclerosis [6,8,20,21]. Studies in several different atherosclerotic models show that treatment with ACE inhibitors and angiotensin receptor blockers almost uniformly inhibit the formation of atherosclerotic lesions [6,22–30]. Wassman et al. [31] also showed that when AT1 receptor-deficient mice were crossed with apoE−/− mice, atherosclerotic lesion formation was reduced.