Serotonin, catecholamines, and spontaneous midgut carcinoid flush: Plasma studies from flushing and nonflushing sites☆,☆☆
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Cited by (41)
Neuroendocrine Gastrointestinal and Lung Tumors (Carcinoid Tumors), the Carcinoid Syndrome, and Related Disorders
2015, Williams Textbook of EndocrinologyCarcinoid Syndrome
2015, Endocrinology: Adult and PediatricNeuroendocrine tumours of the small intestine
2012, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :It may also affect intestinal fluid and electrolyte secretion via 5-HT2A receptors [25]. The flushing phenomenon is attributable to multiple vasoactive substances including prostaglandins, tachykinins and serotonin [26–28]. Flushing typically involves the face, neck and upper torso, and may be precipitated by exercise, stress, alcohol, and certain foods [29].
Cardiovascular manifestations of endocrine dysfunction
2011, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :The mechanism of flushing originally was attributed to serotonin and its metabolites126 because since serotonin can vasodilate directly as well as indirectly via release of nitric oxide.127 However, in many patients, serotonin is clearly not the primary mediator,128,129 and there is evidence for a role of tachykinins,130-132 kallikrein, bradykinins,133,134 and histamine135,136 in different patient populations. A potentially more serious manifestation is subendocardial fibrosis, which typically produces plaque-like thickening of the triscuspid and pulmonic valves.
Neuroendocrine Gastrointestinal and Lung Tumors (Carcinoid Tumors), Carcinoid Syndrome, and Related Disorders
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2010, Endocrinology: Adult and Pediatric, Sixth Edition
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Presented in part at the 94th Annual Meeting of the American Gastroenterological Association, May 1993, in Boston, Massachusetts, and published in abstract form (Gastroenterology 1993; 104:A549).
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The authors thank Drs. J. Callebert, B. Coffin, J. Gombert, O. Bousquet, C. Simonetta (Sandoz), and J. Arsham and C. Delplanque for their skillful technical assistance; Dr. J. Y. Mary for his critical review of the manuscript; Drs. B. Flourié, M. Da Prada, P. R. Saxena, and D. Fekkes for their pertinent advice; Drs. J. C. Rambaud, Ph. Rougier, J. P. Galmiche, L. Le Bodic, D. Cloarec, and A. Bitoun for referral of patients; and Drs. M. Briaud, A. Verneau, and Ph. Beau for assistance in the care of the patients.