Regular articleInduction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation☆
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Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells
2019, Free Radical Biology and MedicineCancer growth regulation by 4-hydroxynonenal
2017, Free Radical Biology and MedicineCitation Excerpt :Awasthi et al. showed that HNE differentially affect K562 cells overexpressing mGSTA4 cells, thus making them less susceptible to HNE-induced differentiation and apoptosis [24]. One of the first discoveries in studies on regulatory biological effects of HNE was observation that HNE can induce differentiation of K562 and of HL-60 leukemic cells [25,26]. Differentiation of HL-60 cells by HNE is initiated by an huge increase in peroxisome proliferation activating receptor γ (PPARγ), but not of PPARα expression, indicating targeted effects of HNE on PPARγ ligands [27].
Signaling by 4-hydroxy-2-nonenal: Exposure protocols, target selectivity and degradation
2017, Archives of Biochemistry and BiophysicsCitation Excerpt :To mimic a stable HNE level for longer exposure time as is observed in vivo, many studies treat cells with a repeated additions of HNE [50–55]. Such an exposure mode was first used by Barrera et al. to investigate HNE effects on cell differentiation [56]. This group systematically measured and compared HNE concentration in cell medium after bolus or repeated addition of HNE [57].
The inclusion complex of 4-hydroxynonenal with a polymeric derivative of β-cyclodextrin enhances the antitumoral efficacy of the aldehyde in several tumor cell lines and in a three-dimensional human melanoma model
2013, Free Radical Biology and MedicineCitation Excerpt :A similar observation can be made for PC3 and A375 cells treated with 10 μM free HNE, in that faint bands of cleaved PARP can be observed at 24 h in both cell lines, paralleling a weak, but significant, increase in stained trypan blue cells at 72 h. Further, in HL-60 cells, we have demonstrated that 10 μM HNE/PACM-βCD induced not only apoptosis but also cellular differentiation, whereas a single treatment with 10 μM free HNE did not. We previously demonstrated that differentiation induction occurred when HL-60 cells were maintained for 7.5 h in the presence of 1 μM HNE through the protocol of repeated treatments [34]. Thus, it appears that the induction of cell differentiation, which was higher with 10 μM HNE/PACM-βCD than with 10 μM free HNE treatment, can be related to the increased permanence of the aldehyde in the cell culture.
Oxidative Stress in Cultured Animal Cells
2012, Animal Cell BiotechnologyNuclear factor erythroid 2-related factor-2 activity controls 4-hydroxynonenal metabolism and activity in prostate cancer cells
2011, Free Radical Biology and MedicineCitation Excerpt :These first observations indicated that HNE may control, even with different effectiveness, prostate cancer growth. Although these effects have been evidenced at supraphysiological concentrations of HNE, it has been demonstrated, in PC3 cancer cells and in other models of tumors, that HNE can exert analogous effects even if added at physiologically achievable concentrations for prolonged times [26–28]. On the other hand, HNE is normally found in human plasma at concentration of 0.65 μM in healthy subjects [29] and has been found in normal prostate as well as in precancerous and cancerous lesions [30,31].
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This work was supported by the Association for International Cancer Research (U.K.) and by Consiglio Nazionale delle Ricerche (Special Project Oncology) Roma, Italy.