The establishment of a line (WISH) of human amnion cells in continuous cultivation☆
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Targeting senescent cells for vascular aging and related diseases
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Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders
2020, Ageing Research ReviewsCitation Excerpt :Although past studies have identified common cellular and molecular traits associated with cell senescence, biological differences existing between the chronological aging phenotype and damage or stress response-associated premature senescence still remain largely unknown (Hernandez-Segura et al., 2017). Replicative senescence is mainly induced by telomeric dysfunction (telomere uncapping) as a result of repeated cell division (Hayflick, 1961), whereas a plethora of stress can provoke premature cellular senescence including mitochondria deterioration, oxidative stress, DNA damage and the expression of certain oncogenes (Coppè et al., 2010; Sahin and Depinho, 2010). So far, cellular senescence is not a time-defined process: each cell will enter into senescence conforming to its own history, and according to the speed of its proliferation.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination
2012, Gynecologic OncologyCitation Excerpt :Profiling of these cells (Table 3) indicated that they are identical at all loci to HeLa cervical carcinoma cells, specifically the HeLaS3 variant. HES cells are also identical to WISH cells, a cell line originally described as derived from human amnion [61] but subsequently also identified as HeLa [7,62,63]. These results were independently confirmed by the STR fragment analysis facility at Johns Hopkins University (D. Kniss, Ohio State University; personal communication).
Purification and refolding of recombinant human interferon-gamma in urea-ammonium chloride solution
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This work was supported by a grant (C-4534) from the National Institutes of Health, United States Public Health Service.