Behavioral pharmacologyAlcohol drinking is reduced by a μ1- but not by a δ-opioid receptor antagonist in alcohol-preferring rats
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Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats
2021, Pharmacology Biochemistry and BehaviorCitation Excerpt :Notably, the behavioral effects of SAM are likely driven by activity at multiple opioid receptors. For example, selective μ- (Honkanen et al., 1996; Stromberg et al., 1998) and δ-opioid receptor antagonists (Hyytia and Kiianmaa, 2001; Krishnan-Sarin et al., 1995) block ethanol-seeking behavior, while κ-opioid receptor antagonists generally have no effect on oral ethanol self-administration in non-dependent rats (however, see (Mitchell et al., 2005)). In contrast, SAM produced a nonsignificant decrease in FR cocaine self-administration.
Rat animal models for screening medications to treat alcohol use disorders
2017, NeuropharmacologyCitation Excerpt :Major concurrent measures would include body weight as well as food and water intake to detect secondary effects. Examples of neurotransmitters modulating the maintenance of ethanol intake include the adrenergic (alpha: Froehlich et al., 2013a), cannabinoid (Dyr et al., 2008; Gessa et al., 2005; Hansson et al., 2007), cholinergic (Bell et al., 2009a; Sotomayor-Zarate et al., 2013), dopaminergic (Dyr et al., 1993; Thanos et al., 2005), GABAergic (GABRA: Agabio et al., 1998; GABRA-BDZ complex: June et al., 1998b; McKay et al., 2004; GABRB: Maccioni et al., 2012; Quintanilla et al., 2008), glutamatergic (Bilbeny et al., 2005; Cowen et al., 2005b; Sari et al., 2013a), histaminergic (Lintunen et al., 2001), opioid (pan-opioid: Hyytiä and Sinclair, 1993; June et al., 1998d; MOR: Honkanen et al., 1996; Krishnan-Sarin et al., 1998; DOR: Hyytiä and Kiianmaa, 2001; sigma: Sabino et al., 2009a), and serotonergic (Long et al., 1996; Overstreet et al., 1997; Panocka et al., 1995b; West et al., 2011) systems (Table 5). Overall, the neurotransmitter systems most often tested across the lines have been the (a) cannabinoid system in six of the selectively bred rat lines, (b) GABAergic system in five of the selectively bred lines as well as Sprague-Dawley and Long-Evans Hooded outbred lines, and (c) opioid system in six of the selectively bred rat lines as well as Sprague-Dawley and Wistar outbred lines.
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2016, Neuropathology of Drug Addictions and Substance Misuse Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and OpioidsAnimal models for medications development targeting alcohol abuse using selectively bred rat lines: Neurobiological and pharmacological validity
2012, Pharmacology Biochemistry and Behavior