Action of β-phenylethylamine and related amines on nigrostriatal dopamine neurotransmission
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2014, Neurochemistry InternationalCitation Excerpt :Moreover, in vivo studies showed that physiological βPEA concentrations directly and transiently inhibit the firing rate of the DA neurons through the activation of the DA D2 autoreceptors (Ishida et al., 2005; Mercuri et al., 1997; Rodriguez and Barroso, 1995). Interestingly, the firing inhibition caused by βPEA as well as βPEA-induced behaviors (Barroso and Rodriguez, 1996) were not affected by pretreatment with the vesicular monoamine transporter (VMAT) blocker reserpine. These data suggested that βPEA stimulates the release of DA from a non-vesicular cytoplasmic pool.
Selective monoamine oxidase B inhibition by an Aphanizomenon flos-aquae extract and by its constitutive active principles phycocyanin and mycosporine-like amino acids
2014, PhytomedicineCitation Excerpt :As a possible explanation of these reported effects, it has been found that Klamath Lake's AFA contains varying but significant quantities of phenylethylamine (PEA), ranging from 1 to 3 mg/gr, which are brought to a concentration of 15 mg/gr in the Klamin® extract. PEA is considered responsible for affective behavior (Sabelli and Javaid, 1995); indeed, the most important action of PEA is to promote the neurotransmission of catecholamines, not only by stimulating their release but also by acting as a fast and physiological reuptake-inhibitor of dopamine (Barroso and Rodriguez, 1996). At the same time, PEA can also modulate the transmission of serotonin (Sabelli and Javaid, 1995) and depress neurotransmission if needed (Federici et al., 2005).