Molecular and cellular pharmacologyPharmacology of muscarinic acetylcholine receptor subtypes (m1–m5): high throughput assays in mammalian cells
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2018, Pharmacology and TherapeuticsRole of acetylcholine in control of sexual behavior of male and female mammals
2014, Pharmacology Biochemistry and BehaviorCitation Excerpt :More recently, it has been suggested that the sometimes perplexing effects of systemically-administered cholinergic drugs could relate instead to differences in drug affinities for mAChR subtypes (Floody, 2013; Floody and Lusk, 2013). In particular, some results suggest that OXO prefers M2 (or M2 and M4) receptors whereas SCO binds all subtypes to similar extents (Bräuner-Osborne and Brann, 1996; Dohanich et al., 1991; Ehlert and Tran, 1990; Gattu et al., 1997; Levey et al., 1991; Murakami et al., 1996; Vilaró et al., 1992, 1994). Such differences could explain several aspects of the effects on male sexual behavior, including (a) the relative specificity of the facilitation sometimes produced by OXO (Ahlenius and Larsson, 1985; Retana-Marquez et al., 1993), (b) the consistency with which SCO is able to reverse these effects (e.g., Ahlenius and Larsson, 1985), and (c) SCO's ability to sometimes go beyond a simple reversal by affecting additional measures and producing disproportionally large behavioral decrements (e.g., Retana-Marquez et al., 1993).
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2013, Neuroscience and Biobehavioral ReviewsResponses to central oxotremorine and scopolamine support the cholinergic control of male mating behavior in hamsters
2013, Pharmacology Biochemistry and BehaviorCitation Excerpt :However, one possible dimension that may be relevant emerges from reports of possible differences in the relative affinities of OXO and SCO for the five or more receptors (M1–M5) thought to jointly mediate muscarinic responses. In particular, some results suggest a preference by OXO for M2, or M2 and M4, receptors that is not shared with SCO (e.g., Bräuner-Osborne and Brann, 1996; Ehlert and Tran, 1990; Gattu et al., 1997; Levey et al., 1991; Murakami et al., 1996; Pilar-Cuéllar et al., 2008; Sánchez et al., 2009; Thomsen et al., 2010; Vilaró et al., 1992, 1994). A difference of this sort would have a variety of implications.