α2D-Adrenoceptors modulate renal noradrenaline release in normotensive and spontaneously hypertensive rats
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Evolution of the α<inf>2</inf>-adrenoreceptors in vertebrates: ADRA2D is absent in mammals and crocodiles
2017, General and Comparative EndocrinologyCitation Excerpt :Within the vertebrate clade, we recovered five monophyletic groups that correspond to the three already well characterized α2-adrenoreceptor genes (ADRA2A, ADRA2B and ADRA2C), a clade that corresponds to the fourth member of the α2-adrenoreceptor gene family (ADRA2D), and in agreement with previous studies a single clade that contains the ADRA2 sequences of two lamprey species (Yamamoto and Vernier, 2011) (Fig. 1). It is important to note that the ADRA2D clade we identified in our phylogenetic analyses does not correspond to the clade that includes the α2-adrenoreceptor gene of rat, mouse and cow that in the past was named ADRA2D (Bohmann et al., 1994; Kobayashi et al., 2004; Bylund, 2005). The use of the name ADRA2D to refer to the clade including the α2-adrenoreceptor gene of rat, mouse, and cow was assigned based on pharmacological assays; specifically, lower affinity of yohimbine and rauwolscine for the receptor.
[<sup>3</sup>H]RX821002 [2-methoxyidazoxan) binds to α<inf>2</inf>-adrenoceptor subtypes and a non-adrenoceptor imidazoline binding site in rat kidney
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