Modulation of striatal adenosine A1 and A2 receptors induces rotational behaviour in response to dopaminergic stimulation in intact rats

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Abstract

The intraperitoneal injection of d-amphetamine (5 mg/kg i.p.), preceded (10 min before) by intrastriatal injection of an adenosine A2 receptor agonist (CGS 21680, 5–10 μg) or followed (5 min later) by an intrastriatal adenosine A1 receptor agonist (N6-cyclopentyladenosine, CPA, 30 μg), induced ipsilateral rotations in rats. The opposite effect (contralateral rotations) was observed with adenosine receptor antagonist (A2, 3,7-dimethyl-1-propargylxanthine, DMPX, 10 μg; A1 antagonist, 8-cyclopentyl-1,3-dimethylxanthine, CPT, 2.5 μg). These results confirm that both adenosine A2 and A1 receptors modulate striatal dopaminergic neurotransmission.

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