Adenosine A3 receptor stimulation and cerebral ischemia

doi:10.1016/0014-2999(94)90523-1

European Journal of Pharmacology

Volume 263, Issues 1–2, 22 September 1994, Pages 59-67

https://doi.org/10.1016/0014-2999(94)90523-1 Get rights and content

Abstract

Chronic treatment with the selective adenosine A₃ receptor agonist $N^{6} -(3- iodobenzyl) adenosine -5′-N- methylcarboxamide$ (IB-MECA) administered prior to either 10 or 20 min forebrain ischemia in gerbils resulted in improved postischemic blood flow, enhanced blood circulation, survival, and neuronal preservation. Opposite effects, i.e., impaired postischemic blood flow, enhanced mortality, and extensive neuronal destruction in the hippocampus were seen when IB-MECA was given acutely. Neither adenosine A₁ nor A₂ receptors are involved in these actions. The data indicate that stimulation of adenosine A₃ receptors may play an important role in the development of ischemic damage, and that adenosine A₃ receptors may offer a new target for therapeutic interventions.

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¹: On leave from the Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.

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Adenosine A3 receptor stimulation and cerebral ischemia

Abstract

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Adenosine A₃ receptor stimulation and cerebral ischemia