Chronic treatment with haloperidol modifies the sensitivity of autoreceptors that modulate dopamine release in rat striatum

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Abstract

The effects of apomorphine or sulpiride on electrically evoked dopamine release from striatal slices of rats pretreated with haloperidol were investigated. Chronic haloperidol treatment (1 mg/kg per day for 21 days) significantly reduced electrically evoked dopamine release from striatal slices until 72 h after the last injection. The apomorphine-induced reduction and the sulpiride-induced increase in evoked dopamine release were significantly enhanced by the chronic treatment with haloperidol at 72 h after the last injection. The enhancement of the sulpiride-induced increase in evoked dopamine release was inversely correlated with the dopamine release evoked by the first stimulation in striatal slices from haloperidol-treated (r = −0.85, n = 12, P < 0.01) but not from saline-treated rats. These results suggest that an increase in the sensitivity of dopamine autoreceptors due to chronic treatment with haloperidol could partially account for the reduction in dopamine release from striatal slices of rats.

References (34)

  • B.A. Bunney et al.

    The effect of antipsychotic drugs on the firing of dopaminergic neurons. A reappraisal

  • D.R. Burt et al.

    Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

    Science

    (1977)
  • W.H. Chang et al.

    Acute and chronic effects of haloperidol on plasma and brain homovanillic acid in the rat

    Biol. Psychiat.

    (1986)
  • L.A. Chiodo et al.

    Typical and atypical neuroleptics: Differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

    J. Neurosci.

    (1983)
  • A. Crow et al.

    Striatal dopamine receptors become supersensitive while rats are given trifluoperazine for six months

    Nature

    (1979)
  • K. Dismukes et al.

    Effects of neuroleptics on release of [3H]-dopamine from slices of rat corpus striatum

    Naunyn-Schmiedeb. Arch. Pharmacol.

    (1977)
  • L. Dwoskin et al.

    Robust modulation of [3H]-dopamine release from striatal slices by D-2 dopamine receptors

    J. Pharmacol. Exp. Ther.

    (1986)
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