Enkephalin antinociception in mice is mediated by δ1- and δ2-opioid receptors in the brain and spinal cord, respectively
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Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine
2020, European Journal of PharmacologySandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: Studies on the endogenous opioid peptide α-neoendorphin
2013, Bioorganic and Medicinal Chemistry LettersGeneration of novel radiolabeled opiates through site-selective iodination
2011, Bioorganic and Medicinal Chemistry LettersFurther analyses of mechanisms underlying the antinociceptive effect of the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene in mice
2011, European Journal of PharmacologyCitation Excerpt :They also signal in similar ways, coupling to guanine nucleotide binding regulatory proteins (Gi/o) to inhibit adenylyl cyclase, open inner-rectifying K+ channels and inactivate L-type and N-type Ca2+ channels. All three of these receptors mediate analgesia in the spinal cord (Budai and Fields, 1998; Chen and Pan, 2006; Chen et al., 2007; Takemori and Portoghese, 1993). In the present study, we showed that the opioid system is involved in the antinociceptive effect induced by TTHL.
Opioids modulate pain facilitation from the dorsal reticular nucleus
2008, Molecular and Cellular Neuroscience
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