Short communicationAmitriptyline inhibits striatal efflux of neurotransmitters via blockade of voltage-dependent Na+ channels
References (15)
- et al.
Tricyclic antidepressant inhibition of depolarization-induced uptake of calcium by synaptosomes from rat brain
Biochcm. Pharmacol.
(1985) - et al.
Effect of imipramine un calcium and potassium currents in isolated bovine ventricular myocytes
Eur. J. Pharmacol.
(1985) - et al.
[3H]Batrachotoxinin A 20-α-benzoate binding to sodium channels in rat brain: characterization and pharmacological significance
Eur. J. Pharmacol.
(1986) - et al.
Stimulation of dopamine relase in the rat neostriatum in vivo by activation of the voltage-sensitive sodium channel by scorpion venom neurotoxin
Brain Res.
(1989) - et al.
Evoked release of endogenous amino acids from rat striatal slices and its modulation
Eur. J. Pharmacol.
(1989) - et al.
Release of endogenous acetylcholine from rat brain slices with or without cholinesterase inhibition and its potentiation by hemicholinium-3
Neurosci. Lett.
(1990) - et al.
Decrehse in the evoked release of endogenous dopamine and dihydroxyphenylacetic acid from rat striatal slices after repeated haloperidol
Eur. J. Pharmacol.
(1990)
Cited by (26)
Compound action potential inhibition produced by various antidepressants in the frog sciatic nerve
2018, European Journal of PharmacologyCitation Excerpt :The CAP amplitude reductions produced by the antidepressants may be due to an inhibition of TTX-sensitive voltage-gated Na+ channels which are involved in the production of frog CAPs (Katsuki et al., 2006; Mizuta et al., 2008). In support of this idea, voltage-gated Na+ channels were inhibited by duloxetine (Stoetzer et al., 2016; Wang et al., 2010), fluoxetine (Pancrazio et al., 1998), amitriptyline (Ishii and Sumi, 1992; Leffler et al., 2007; Nicholson et al., 2002; Pancrazio et al., 1998; Song et al., 2000; Stoetzer et al., 2016; Wang et al., 2004; Yan et al., 2010), desipramine and maprotiline (Dick et al., 2007). The efficacy sequence of amitriptyline > fluoxetine ≧ desipramine for frog sciatic nerve CAP inhibition was similar to that of Na+-channel inhibition in bovine chromaffin cells (Pancrazio et al., 1998).
An open labeled randomized controlled trial of pregabalin versus amitriptyline in chronic low backache
2014, Journal of the Neurological SciencesCitation Excerpt :Tricyclic antidepressants inhibit the presynaptic reuptake of the monoamines, serotonin and noradrenaline [25]. It has repeatedly been shown in experiments in vitro that tricyclic antidepressants block sodium channels and this effect is also seen in neuronal tissue [26–28]. Pregabalin is a more specific α2-δ ligand with a sixfold-higher binding affinity than gabapentin.
Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain
2009, Pharmacology and TherapeuticsNeurotropic and psychotropic drugs in dermatology
2001, Dermatologic ClinicsCitation Excerpt :Local anesthetics and antiepileptic drugs having sodium channel–blocking abilities are effective in treating neuropathic pain. Finally, TCAs block potassium channels.69 Doxepin is a tertiary amine used in treatment of neurotic excoriations, chronic urticaria, and generalized pruritus.
Amitriptyline modulation of Na<sup>+</sup> channels in rat dorsal root ganglion neurons
2000, European Journal of Pharmacology
- 1
Research fellow from Omiya Research Laboratory, Nikken Chemical Co., Ltd., 1-346 Kitabukuro-Chyo, Omiya, Saitama 330, Japan.