Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats

doi:10.1016/0014-2999(92)90065-C

European Journal of Pharmacology

Volume 212, Issue 1, 25 February 1992, Pages 9-13

https://doi.org/10.1016/0014-2999(92)90065-C Get rights and content

Abstract

The mechanism of the inhibitory action of rebamipide, a new mucosal protective drug, was studied using rats with diethyldithiocarbamate-induced gastric antral ulcers. Rebamipide reduced ulcer formation and inhibited the elevation in lipid peroxide concentration in the gastric mucosa. Rebamipide inhibited both luminol- and lucigen-dependent chemiluminescence of neutrophils activated by formyl-methionyl-leucyl-phenylalanine. Rebamipide did not alter the reduction of cytochrome c induced by the xanthine-xanthine oxidase system or the NADPH-dependent micirosomal lipid peroxidation in the liver. These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.

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Citation Excerpt :
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Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats

Abstract

Anal. Biochem.

Meth. Enzymol.

Biochem. Biophys. Res. Commun.

J. Biol. Chem.

Gastroenterology

J. Biol. Chem.

Gastroenterology

Anal. Biochem.

Gastroenterology

Gastroenterology

Blood

Am. J. Clin. Nutr.

Alteration by prostaglandins and indomethacin of the mouse peritoneal macrophage oxidative burst

Br. J. Pharmacol.

Role of myeloperoxidase in luminol-dependent chemiluminescence of polymorphonuclear leukocytes

Infect. Immun.

Pattern of formyl-methionyl-leucyl-phenylalanine-induced luminol- and lucigenin-dependent chemiluminescence in human neutrophils

Infect. Immun.

Mechanism of the luminol-dependent chemiluminescence of human neutrophils

J. Immunol.

Xanthine oxidase and neutrophil infiltration in intestinal ischemia

Am. J. Physiol.

Gastric antral ulcers induced by a combination of acid, indomethacin and ischemia in rats

Jap. J. Pharmacol.