Behavioral and biochemical effects of the 5-HT1A receptor agonists flesinoxan and 8-OH-DPAT in the rat
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The neurobiology of the male sexual refractory period
2018, Neuroscience and Biobehavioral ReviewsThe role of adrenoceptors in the central nervous system in male and female rat sexual behavior
2015, European Journal of PharmacologyCitation Excerpt :At first sight, the existing literature suggests that serotonergic agents have opposite effects on male and female rat sexual behavior. 5-HT1A receptor agonists, for example, facilitate sexual behavior in male rats (Ahlenius et al., 1991; Foreman et al., 1994; Haensel and Slob, 1997; Hillegaart and Ahlenius, 1998; Johansson et al., 1991; Mendelson and Gorzalka, 1986; Schnur et al., 1989), but inhibit female sexual activity (Ahlenius et al., 1986, 1989; Fernandez-Guasti et al., 1987; Kishitake and Yamanouchi, 2003; Mendelson and Gorzalka, 1986). This seems quite conflicting, but it could simply be due to our definitions of different elements of sexual behavior.
Sexual side effects of serotonergic antidepressants: Mediated by inhibition of serotonin on central dopamine release?
2014, Pharmacology Biochemistry and BehaviorCitation Excerpt :5-HT1A receptor agonists, including buspirone, have prosexual activity in rats upon acute administration (de Jong et al., 2006; Pattij et al., 2005). ( Ahlenius et al., 1991; Fernandez-Guasti et al., 1992) (for an extensive review about the involvement of serotonin 1A receptors in the regulation of male sexual behavior, see Snoeren et al. in the current issue). Based on the 5-HT tonic inhibition theory, this effect is suggested to be due to decreased 5-HT tonic inhibition following 5HT1A autoreceptor activation.
Serotonin 1A receptors and sexual behavior in male rats: A review
2014, Pharmacology Biochemistry and BehaviorCitation Excerpt :This is mainly based on studies showing the effects of 5-HT1A receptor agents. In rats, the 5-HT1A receptor agonist (±)8-OH-DPAT and its active enantiomer (+)8-OH-DPAT have a very clear facilitatory effect on the executive phase by decreasing the latency to first ejaculation (Ahlenius et al., 1991; Foreman et al., 1994; Haensel and Slob, 1997; Hillegaart and Ahlenius, 1998; Johansson et al., 1991; Mendelson and Gorzalka, 1986; Schnur et al., 1989). The effect on the copulatory phase is less clear.
Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice
2012, Behavioural Brain Research