Elsevier

European Journal of Pharmacology

Volume 202, Issue 2, 17 September 1991, Pages 277-280
European Journal of Pharmacology

Short communication
Loperamide but not morphine has anti-secretory effects in human colon, in vitro

https://doi.org/10.1016/0014-2999(91)90305-AGet rights and content

Abstract

Isolated preparations of human colonic mucosa were set up in Ussing chambers. Noradrenaline reduced basal short-circuit current, morphine did not nor did loperamide except at the highest concentration tested. Electrically evoked increases in short-circuit current were unaffected by morphine but reduced by loperamide, by a naloxone-insensitive mechanism. Unidirectional fluxes of 22sodium and 36chloride were unaffected by morphine. It is concluded that loperamide but not morphine has an anti-secretory effect on human colonic mucosa.

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