Reduction of ischemic damage in isolated rat hearts by the potassium channel opener, RP 52891
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The Discovery of Myocardial Preconditioning Using Volatile Anesthetics: A History and Contemporary Clinical Perspective
2018, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :In a remarkably productive display of scientific creativity during the following 3 years,149 Gross published a series of articles in rapid succession that further defined the KATP channel-dependence of IPC150–152 and myocardial stunning131 and demonstrated that G protein-linked receptor ligands, including acetylcholine (through the muscarinic type 2 receptor),153,154 adenosine (A1 receptor),155,156 and opioids (delta type 1 receptor),157,158 mimicked these phenomena through their actions on KATP channels.159 These latter investigations firmly established the concept of “pharmacological preconditioning” suggested earlier by Grover140–142 and Downey.137 From the perspective of the current discussion, it is notable that Warltier was a university colleague and frequent collaborator with Gross; the 2 researchers published more than 80 articles together through 1993,ǁ including 2 that described the role of KATP channels in myocardial ischemic injury.160,161
Mitochondrial potassium transport: The role of the mitochondrial ATP-sensitive K<sup>+</sup> channel in cardiac function and cardioprotection
2003, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :Grover et al. [19] were the first to evaluate KCOs for their ability to protect the heart against ischemia–reperfusion injury. They found cromakalim and pinacidil to be protective in the perfused rat heart model [19], and subsequently showed that other KCOs, including bimakalim, aprikalim, and P-1075, also protected isolated rat hearts [28–30]. Investigators have demonstrated cardioprotection by KCOs in isolated hearts from rats, rabbits, ferrets, and guinea pigs [31–36].
ATP-sensitive potassium channels: A review of their cardioprotective pharmacology
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