5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord
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Ultrastructure of the serotonin innervation in mammalian central nervous system
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :These synaptic contacts are then mostly found on dendritic profiles, occasionally on somata and rarely on dendritic spines. Because 5-HT1 and 5-HT3 receptors are known to be present on primary afferent axons of the dorsal horn (Daval, Vergé, Basbaum, Bourgoin, & Hamon, 1987; Hamon et al., 1989), but no axoaxonal synaptic contacts are made by its 5-HT afferents, it is likely that diffuse 5-HT transmission controls the release of neurotransmitters from these as well as the spinal cord nociceptive afferents (Li et al., 1997). In the rat motor trigeminal nucleus, the density of 5-HT innervation has been estimated at 1.8 × 106 varicosities per mm3 of tissue (Schaffar, Jean, & Calas, 1984).
Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT<inf>2A</inf> and 5-HT<inf>3</inf> receptors
2013, European Journal of PharmacologyCitation Excerpt :Similar controversial results were also reported for pain sensation, i.e., 5-HT3 receptors were shown to mediate both pronociceptive (Ali et al., 1996; Oyama et al., 1996) and antinociceptive effects in the spinal cord (Alhaider et al., 1991; Bardin et al., 2000; Giordano, 1997). 5-HT3 receptors are also expressed in the terminals of afferent C fibers in the dorsal horn (Hamon et al., 1989; Kidd et al., 1993; Morales et al., 2001). It is likely that bath-applied 5-HT and its analogs affect 5-HT3 receptors in different regions from those affected by endogenously released 5-HT, which may be a crucial factor behind the conflicting reports on the facilitatory and inhibitory effects of 5-HT in the spinal cord.
5-HT<inf>3</inf> receptors: Role in disease and target of drugs
2010, Pharmacology and TherapeuticsCitation Excerpt :Pain perception is mediated either via sensory nociceptors in terms of sensory pain or after nerve damage causing neuropathic pain. Expression of 5-HT3 receptors on primary afferents (Hamon et al., 1989), which transmit sensory and nociceptive input from the periphery to the brain, makes them excellent candidates for investigation of pain perception. 5-HT activates presynaptic 5-HT3 receptors on central terminals of spinal afferents, thereby increasing the spinal transmission via the dorsal horn and resulting in increased pain and reflex responses (Suzuki et al., 2002).
Serotonin in Pain and Pain Control
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :Excellent reviews on this subject have been published recently (Millan, 2002; Suzuki et al., 2004b; Lopez-Garcia, 2006; Yoshimura and Furue, 2006). In particular, 5-HT2A and 5-HT3 receptors, among others (Hamon and Bourgoin, 1999; Nicholson et al., 2003), are expressed by primary afferent fibers that convey nociceptive messages from the periphery to the CNS (Hamon et al., 1989; Carlton and Coggeshall, 1997). 5-HT presynaptically inhibits the glutamate release from nociceptors, but the receptor responsible for this effect has not yet been identified (I to et al., 2000).
Ultrastructure of the Serotonin Innervation in the Mammalian Central Nervous System
2010, Handbook of Behavioral NeuroscienceThe effect of serotonin on GABA synthesis in cultured rat spinal dorsal horn neurons
2008, Journal of Chemical Neuroanatomy