Effect of S-adenosyl-L-methionine on impairment of working memory induced in rats by cerebral ischemia and scopolamine
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Cited by (16)
Effect of S-adenosyl-L-methionine on rat brain oxidative stress damage in a combined model of permanent focal ischemia and global ischemia-reperfusion
2000, Brain ResearchCitation Excerpt :Mabe et al. [26] showed that SAM normalized ATP levels that had been lowered in a model of brain ischemia; this effect improved the supply of energy to the neurons, and thus neuronal functioning. This mechanism was cited by Yatsugi et al. [38] to explain their finding that SAM improved memory impairments in rats subjected to brain ischemia. An additional factor that cannot be ruled out is a hypothetical neuroprotective effect of SAM based on its demonstrated antioxidant action, as other antioxidant substances have been shown to have a neuroprotective effect [2,11–16,37].
Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents
1997, European Journal of PharmacologyEffect of S-adenosyl methionine on muscarinic receptors in young rats
1997, Life SciencesRepeated acquisition and the assessment of centrally acting compounds
1996, Cognitive Brain Research
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Present address: Department of Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., 1-8 Azusawa 1-chome, Itabashi-ku, Tokyo 174, Japan.
Copyright © 1989 Published by Elsevier B.V.