Electrophysiological effects of methylphenidate on the coeruleo-cortical noradrenergic system in the rat
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Cited by (23)
Lack of zinc finger protein 521 upregulates dopamine β-hydroxylase expression in the mouse brain, leading to abnormal behavior
2019, Life SciencesCitation Excerpt :In children affected by attention deficit hyperactivity disorder (ADHD), altered DA due to dysfunction of Pfc has been reported [13]. Drugs that regulate NA transmission, such as methylphenidate and amphetamine, are effective for patients with ADHD [14,15] and return the quantitative DA and NA balance closer to the normal state [16–18]. Given these findings, we suggest that DA/NA imbalance due to decreased DA and increased NA in the brain causes the abnormal behavior of Zfp521Δ/Δ mice, including hyperlocomotion and reduced anxiety.
Atomoxetine modulates spontaneous and sensory-evoked discharge of locus coeruleus noradrenergic neurons
2013, NeuropharmacologyCitation Excerpt :Finally, analysis of coherence values between cortical EEG and LFP recorded in the LC showed that a low ATM dose decreased, whereas higher doses increased synchronized activity between these two brain regions. The decrease in tonic LC activity after ATM is similar to what has been observed after administration of methylphenidate (Devilbiss and Berridge, 2006; Lacroix and Ferron, 1988; Olpe et al., 1985), amphetamine (Graham and Aghajanian, 1971; Ryan et al., 1985), cocaine (Curtis et al., 1993; Pitts and Marwah, 1987) and several NE reuptake inhibitors (Aghajanian, 1980; Nyback et al., 1975; Olpe et al., 1983; Scuvee-Moreau and Dresse, 1979; Valentino et al., 1990; Wong et al., 2000). This effect is mediated by indirect activation of inhibitory presynaptic α2 noradrenergic receptors and is blocked by co-administration of α2 antagonists (Fernandez-Pastor et al., 2005; Grandoso et al., 2004; Mateo et al., 1998; Miguelez et al., 2009; Starke and Montel, 1973; Svensson et al., 1975; Svensson and Usdin, 1978; Wong et al., 2000).
Methylphenidate modulates the locus ceruleus neuronal activity in freely behaving rat
2012, European Journal of PharmacologyCitation Excerpt :Consistent with the above studies, the present experiment found that after administration of MPD most of LC units significant increase their firing rate, since administration of MPD (2.5 mg/kg or above) resulted in an increase in locomotor activity (Askenasy et al., 2007; Gaytan et al., 2000a, 2000b, 2002; Yang P.B. et al., 2003a, 2006a, 2006b, 2006c, 2007, 2010). MPD administration elicits a decrease of LC neurons firing rate in anesthetized rats in previous studies, which was explained by the inhibitory feedback of presynaptic α2-adrenergic autoreceptors (Lacroix and Ferron, 1988). Obviously, this mechanism is not accountable for the increase of LC neurons firing rate in our freely moving rats, which, however, can be explained by other two mechanisms.
Pharmacotherapy for Attention-Deficit/Hyperactivity Disorder: From Cells to Circuits
2012, NeurotherapeuticsCentral α<inf>1</inf>-adrenoceptors: Their role in the modulation of attention and memory formation
1999, Pharmacology and Therapeutics