Direct central effects of acute methylenedioxymethamphetamine on serotonergic neurons
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The role of serotonin in drug use and addiction
2015, Behavioural Brain ResearchRecent updates on drug abuse analyzed by neuroproteomics studies: Cocaine, Methamphetamine and MDMA
2014, Translational ProteomicsCitation Excerpt :The fragmentation of these proteins may have been due to either the increased susceptibility of mitochondrial proteins to proteasomal degradations under oxidative stress [145,146] or simply the spontaneous fragmentation of oxidized proteins [147]. It is the quinone metabolites of MDMA, produced via cytochrome P450-catalyzed metabolism, that are important in MDMA-induced organ damage, while the direct administration of MDMA to brain tissue does not cause any tissue damage [148,149]. The main reason for this is that these metabolites produce oxidative and nitrosative stress by the inhibition of the mitochondrial respiratory chain [150–152].
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1- propenes as a new class of anticancer agents
2011, Bioorganic and Medicinal ChemistryCitation Excerpt :Recently, a number of SERT-targeting ligands have been shown to induce apoptosis in a number of malignant cell lines including Burkitt’s lymphoma.2–6 SERT has also been implicated in serotonin-mediated apoptosis in Burkitt’s lymphoma7 and in the mechanism of cytotoxicity associated with the amphetamine analogues, fenfluramine8 and 3,4-methylenedioxymethamphetamine (MDMA).9,10 Although these ligands can target the serotonin transporter, their anticancer effects are thought to occur independently of SERT1,2,11 suggesting that (a) molecular target(s) other than SERT may exist on the lymphoma cell with the possibility of these ligands preferentially targeting the proliferating malignant cell.1
The Role of Serotonin in Drug Addiction
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :However, 5-HT release induced by d-fenfluramine in the FC (Series et al., 1994), and stimulation-evoked 5-HT release in the FC but not in the ventral hippocampus, was markedly decreased after MDMA treatment (Gartside et al., 1996). MDMA exerts potent neurotoxic effects on the 5-HT system (Schmidt, 1987; Schmidt and Taylor, 1988) which are associated with a loss of 5-HT neurons and projections. The 5-HT neurotoxic effects of MDMA are only partially reversible, and may contribute to the long-term behavioral impairments in MDMA users (Quednow et al., 2006, 2007).
Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats
2008, Drug and Alcohol DependenceCitation Excerpt :Deficits in serotonin neurotransmission are common consequences of exposure to MDMA. A single exposure to MDMA was sufficient to decrease indices of serotonin integrity in rats (Schmidt, 1987; Schmidt and Taylor, 1987, 1988; O'Shea et al., 1998) and monkeys (Mechan et al., 2006) for at least a 2 week period whereas more rigorous exposure regimens produced more substantive deficits that persisted for a longer period of time (Sabol et al., 1996; Lew et al., 1996; Scanzello et al., 1993). Depletion of serotonin by 5,7 DHT lesions enhanced cocaine-produced cocaine-seeking (Tran-Nguyen et al., 2001), suggesting an inverse relationship between serotonin and drug-seeking.
Serotonin and psychostimulant addiction: Focus on 5-HT<inf>1A</inf>-receptors
2007, Progress in Neurobiology