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Binding of [125I]Tyr-corticotropin-releasing factor to rabbit aorta is reduced by removal of the endothelium

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    Interestingly, it stimulates cortisol and DHEAS production from fetal adrenals at the end of pregnancy, suggesting a role for CRH in fetal lung maturation and adaptive mechanisms in response to the stress of parturition (Pepe and Albrecht, 1995; Sirianni et al., 2005) (Fig. 2.3). CRH is also a potent vasoactive molecule acting on human vascular endothelium as well as smooth muscle and the feto-placental circulation (Dashwood et al., 1987), and of great physiologic importance during human pregnancy. CRH is a potent relaxant of the uterine arteries and, when administered chronically in pregnant rats, it causes a decrease in blood pressure (Jain et al., 1998).

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