Rapid communicationBinding of [125I]Tyr-corticotropin-releasing factor to rabbit aorta is reduced by removal of the endothelium
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Cited by (40)
The peripheral corticotropin releasing factor family's role in vasculitis
2024, Vascular PharmacologyRole of Acute Myeloid Leukemia (AML)-Derived exosomes in tumor progression and survival
2022, Biomedicine and PharmacotherapyCitation Excerpt :Exosomes derived from human umbilical cord blood carrying MHC-I, MHC-II, CD34, and CD80 activate T cell growth to exert antitumor activity [56]. It has been reported that exosomes secreted from dendritic cells expressing TNF, FasL, and TRAIL attach to TNF receptors on cancer cells and activate caspase initiation of apoptosis [57]. In addition, these nano vesicles can merge with the PM and secret their cargo directly into the cytosol of recipient cells.
Neuroendocrinology of pregnancy and parturition
2014, Handbook of Clinical NeurologyCitation Excerpt :Interestingly, it stimulates cortisol and DHEAS production from fetal adrenals at the end of pregnancy, suggesting a role for CRH in fetal lung maturation and adaptive mechanisms in response to the stress of parturition (Pepe and Albrecht, 1995; Sirianni et al., 2005) (Fig. 2.3). CRH is also a potent vasoactive molecule acting on human vascular endothelium as well as smooth muscle and the feto-placental circulation (Dashwood et al., 1987), and of great physiologic importance during human pregnancy. CRH is a potent relaxant of the uterine arteries and, when administered chronically in pregnant rats, it causes a decrease in blood pressure (Jain et al., 1998).
Urocortin: A protective peptide that targets both the myocardium and vasculature
2009, Pharmacological ReportsCitation Excerpt :Similarly, high levels of CRH-R2β protein have been detected in the rat aortic vascular endothelium [44] and CRH-R2 was detected in human coronary artery and microvascular endothelial cells [74] as well as the endothelium of various other vascular beds [12, 26]. Indeed, ~80% of the specific binding of radio-labeled CRH to rabbit aortas was localized to the endothelial layer [19]. In a particularly informative experiment, sections of human left ventricle were incubated with [125I]-antisauvagine – a truncated form of the amphibian CRH-R agonist “sauvagine”, a receptor antagonist that binds with up to 1000-fold selectivity for CRHR2 [75].
Modulation of endothelial prostaglandin synthesis by corticotropin releasing factor and antagonists
1998, European Journal of Pharmacology