Short communicationA role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine
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[+]-Huperzine A treatment protects against N-methyl-d-aspartate-induced seizure/status epilepticus in rats
2008, Chemico-Biological InteractionsCitation Excerpt :The protection we describe was observed in the absence of atropine and 2-PAM, suggesting that [+]-Hup A offers strong protection against OP-induced seizure/SE (data not included). NMDA receptor antagonists that block the ion-channel tend to produce phencyclidine (PCP) symptoms [41]. However, the physical activity data suggest that locomotor stimulation is not found in these animals after an effective treatment of [+]-Hup A.
N-methyl-D-aspartate antagonists and drug discrimination
1999, Pharmacology Biochemistry and Behavior
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