Anesthetics produce differential actions on the discharge activity of a single neuron
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Cited by (15)
Advances in precision anaesthesia may be found by testing our resistance to change
2020, British Journal of AnaesthesiaThe General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability
2020, iScienceCitation Excerpt :Isoflurane and sevoflurane can induce hyperactivity during anesthesia induction and recovery (Dahmani et al., 2010; Guo et al., 2017; Liang et al., 2017) and immobility at higher concentrations (Sonner et al., 2003). A variety of neuronal functions are bidirectionally modulated by volatile anesthetics (Chen et al., 2018; Yu et al., 2015; MacIver and Roth, 1987, 1988). However, it is unclear how volatile anesthetics bidirectionally modulate neural excitability.
Modulation of Spontaneous and Light-Induced Activity in the Rat Dorsal Lateral Geniculate Nucleus by General Brain State Alterations under Urethane Anesthesia
2019, NeuroscienceCitation Excerpt :Available data suggest that during deep anesthesia (such as during high dose of isoflurane) bursts suppression EEG activity emerge and the thalamo-cortical information flow is prevented (Liu et al., 2011; Lewis et al., 2013; Paasonen et al., 2018). Indeed, in contrast to urethane most anesthetics, including isoflurane, highly promote inhibitory GABAergic transmission or suppress the glutamatergic excitatory activity (MacIver and Roth, 1987; Franks, 2006; Garcia et al., 2010), which may be the cause of sparse neuronal activity of the dLGN observed by us during in vivo recordings. On the other hand, low doses of isoflurane can induce alternations of general brain states, where low frequencies in the ECoG occur, however this pattern does not resemble the natural sleep (Ferron et al., 2009).
Ongoing activity in trigeminal wide-dynamic range neurons is driven from the periphery
2007, NeuroscienceCitation Excerpt :We assume that this unexpected effect is due to the ability of lidocaine at high concentrations to activate the capsaicin receptor TRPV1, as it was seen in TRPV1 expressing human embryonic kidney cells and in capsaicin-sensitive rat dorsal root ganglion neurons (Leffler et al., 2006). The ongoing activity in spinal WDR neurons may depend largely on the state and type of anesthesia, as it is known for activity and synaptic transmission in several types of central neurons (MacIver and Roth, 1987; Morris, 1978). Ongoing activity and receptive field size of spinal WDR neurons have been reported to increase in halothane-anesthetized sheep (Herrero and Headley, 1995).
Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures
2002, European Journal of Pharmacology