Stereospecific binding of the antidepressant rolipram to brain protein structures
References (33)
- et al.
Cyclic nucleotide phosophodiesterases: Properties, activators, inhibitors, structure-activity relations, and possible role in drug development
J. Pharmacol. Sci.
(1975) Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxy cyclic AMP and potassium ions
Biochim. Biophys. Acta
(1984)- et al.
31P NMR studies on intracellular free Mg2+ in intact frog skeletal muscle
J. Biol. Chem.
(1980) - et al.
Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases. Relationship to pharmacological activity
Biochem. Biophys. Res. Commun.
(1983) - et al.
Selective inhibition of one of the cyclic AMP phosphodiesterases from rat brain by the neurotropic compound rolipram
Biochem. Pharmacol.
(1985) - et al.
Brain cAMP and memory in mice
Pharmacol. Biochem. Behav.
(1982) - et al.
[3H]-para-Aminoclonidine: A novel ligand which binds with high affinity to α-adrenergic receptors
Life Sci.
(1979) - et al.
Inhibition of lung cyclic AMP- and cyclic GMP-phosphodiesterases by flavonoids and other chromone-like compounds
Biochem. Pharmacol.
(1981) Brain response to phosphodiesterase inhibitors in rats killed by microwave irradiation or decapitation
Biochem. Pharmacol.
(1984)- et al.
1-Isoamyl-3-isobutylxanthine: A remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices
Life Sci.
(1979)
Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors
Neuropharmacology
Cyclic nucleotide phosphodiesterases
Neurotransmitter, hormone, or drug receptor binding methods
Chromatographische Racemattrennung
Angew. Chem.
Anomalous equilibrium binding properties of high-affinity racemic radioligands
Mol. Pharmacol.
Properties of cyclic nucleotide phosphodiesterase from rat brain
Biochemistry
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Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat model
2017, Neurochemistry InternationalCitation Excerpt :Hence, inhibition of PDE4 enzyme is a way to augment the cAMP level. Previous studies have been reported that inhibition of PDE4 enzyme induces significant rise in cAMP and augments both the intensity and duration of cAMP signaling (Schneider et al., 1986; Scuvee-Moreau et al., 1987). Previous studies from our lab and elsewhere reported that ETZ belongs to PDE4 inhibitor family and treatment with ETZ restored cAMP level (Chasin et al., 1972; Jindal et al., 2012, 2013; 2015a,b).
PDE4D phosphorylation: A coincidence detector integrating multiple signaling pathways
2016, Cellular SignallingCitation Excerpt :Earlier observations had suggested that the interaction UCR1/UCR2 may be affected by the state of phosphorylation at Ser 54 of PDE4D3, including domain interaction monitored by yeast-two-hybrid [31,32]. When radioactive Rolipram was used to probe binding to PDE4 [33], it was discovered that PDE4s assume two conformations: a high affinity (HARBs) or low affinity (LARBs) rolipram binding conformation [34]. It has been proposed that the high affinity state is determined by the UCR2 capping helix providing an additional interaction point for the inhibitor.
Intra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice
2014, Behavioural Brain ResearchCitation Excerpt :One explanation of this result may be differential binding. Other molecules, such as type 1 antiarrhythmic drugs and rolipram exhibit stereospecific binding that is related to molecular rotation of the molecule and differing binding affinity [49,50]. In the case of rolipram, the high affinity binding sites mitigate the antidepressant effects of the drug [51].
Inhibitory effects of hesperetin derivatives on guinea pig phosphodiesterases and Their ratios between high- and low-affinity rolipram binding
2013, Journal of Pharmaceutical Sciences