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Brain dialysis in conscious rats reveals an instantaneous massive release striatal dopamine in response to MPP+

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  • Effects of the Parkinsonian toxin MPP<sup>+</sup> on electrophysiological properties of nigral dopaminergic neurons

    2014, NeuroToxicology
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    Taken together, our results strongly suggest that MPP+ displaces vesicular DA, which interacts with D2 autoreceptors after extracellular release. This indirect action is consistent with previous reports that MPP+ rapidly releases striatal DA in vivo (Rollema et al., 1986; Pileblad et al., 1984) and in striatal brain slices (Markstein and Lahaye, 1984; Schmidt et al., 1984). Although a previous study has shown that MPP+ also releases DA from cultured dopaminergic neurons (Lotharius and O’Malley, 2000), cultured neurons develop numerous axons and axon terminals (Jomphe et al., 2005), making it difficult to distinguish whether DA originated from these terminals or from cell bodies and dendrites.

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    2008, Parkinson's Disease: Molecular and Therapeutic Insights From Model Systems
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