Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice
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2022, Drug and Alcohol DependenceCitation Excerpt :A second group of mice was assessed in the marble burying assay after the dependence induction regimen. Marble burying was measured as previously described (Broekkamp et al., 1986; Kinsey et al., 2011; Trexler et al., 2018). Plastic test chambers (18 cm W x 28 cm L x 12 cm H) filled with Teklad Aspen Sani-Chip (7090 A; Envigo, Indianapolis, IN, USA) wood bedding (5 cm deep) were placed inside a sound-attenuating chamber outfitted with a fan and white LED/infrared lighting.
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2022, Behavioural ProcessesCitation Excerpt :Nowadays, marble burying test is becoming more popular rather than defensive burying test, which is rarely used. Marble burying test is used to distinguish the differences between major and minor tranquillizers on behavior (Broekkamp et al., 1986). It was stated that the inhibition of marble burying could be a model for the detection of anxiolytics (Njung’e and Handley, 1991).
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