The antinociceptive effects of histidyl-proline diketopiperazine and thyrotropin-releasing hormone in the mouse
References (36)
Influence of thyrotropin releasing hormone and histidyl-proline diketopiperazine on spontaneous locomotor activity and analgesia induced by Δ-9-tetrahydrocannabinol in the mouse
European J. Pharmacol.
(1980)Inhibition of abstinence syndrome in opiate dependent mice by cyclo (His-Pro)
Life Sci.
(1981)- et al.
Interactions of thyrotropin releasing hormone, its metabolites and analogues with endogenous and exogenous opiates
Gen. Pharmacol.
(1983) - et al.
Effect of cyclo-leucylglycine in the rat yeast-paw test
European J. Pharmacol.
(1984) - et al.
Thyrotropin releasing hormone antagonizes beta endorphin hypothermia and catalepsy
Life Sci.
(1978) - et al.
Cyclo (His-Pro): mapping hypothalamic sites for its hypothermic action
Brain Res.
(1982) - et al.
Antinociceptive effect of centrally administered cyclo (N-methyl-L-Tyr-L-Arg) in the rat
European J. Pharmacol.
(1983) - et al.
[3H]Cyclo (histidyl-proline) in rat tissues: distribution, clearance and binding
Biochem. Biophys. Res. Commun.
(1982) - et al.
Neuropeptides: influence of acute and chronic effects of opiates
Psychoneuroendocrinology
(1977) - et al.
Analgesic activity of substance P following cerebral administration in rats
Life Sci.
(1978)
Interaction of thyrotropin releasing hormone and morphine sulfate in rodents
Life Sci.
(1977)
Distribution of histidyl-proline diketopiperazine [cyclo (His-Pro)] and thyrotropin-releasing hormone (TRH) in the primate central nervous system
Brain Res.
(1982)
Distribution and characterization of cyclo (His-Pro)-like immunoreactivity in the rat gastrointestinal tract
Biochem. Biophys. Res. Commun.
(1982)
Regional distribution of histidyl-proline diketopiperazine (cyclo (His-Pro)) and thyrotropin-releasing hormone (TRH) in the rat brain
Brain Res.
(1982)
Histidyl-proline diketopiperazine decreases food intake in rats
Brain Res.
(1981)
Analgesic activity of substance P in rats: apparent mediation by met-enkephalin release
Life Sci.
(1982)
Thermoregulation in rats: opposing effects of thyrotropin-releasing hormone and its metabolite histidyl-proline-diketopiperazine
Biochem. Biophys. Res. Commun.
(1978)
Demonstration of two separate enzymatic activities for the degradation of thyrotropin-releasing hormone in hamster hypothalamic extracts
J. Biol. Chem.
(1976)
Cited by (17)
Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain
2011, Brain ResearchCitation Excerpt :Previous studies showed that TRH and its analog taltirelin have antinociceptive effects in mice under normal conditions, mainly via supraspinal actions. For examples, intracerebroventricular administration of TRH and its metabolite significantly attenuated acute pains induced by pressure and heat stimulation (Kawamura et al., 1985). Tanabe et al. (2007) also demonstrated that subcutaneous or intracerebroventricular injection of taltirelin exerted antinociceptive effects by activating the descending noradrenergic and serotonergic pain inhibitory systems, while blocking the opioid system with naloxone did not alter antinociceptive effect of taltirelin.
Bioactive cyclic dipeptides
1995, Peptides
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