Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds
References (37)
- et al.
Interaction of tricyclic antidepressants with opiate receptors
Biochem. Pharmacol.
(1980) - et al.
Influence of naloxone and methysergide on the analgesic effect of clomipramine in rats
European J. Pharmacol.
(1981) - et al.
Effects of antidepressant drugs on different receptors in the brain
European J. Pharmacol.
(1981) - et al.
Effects of increasing serotonergic receptor activity in brain on analgesic activity in rats
Exp. Neurol.
(1980) - et al.
Increased sensitivity of the central nervous system to morphine analgesia by amitriptyline in naive and morphine tolerant rats
Biochem. Pharmacol.
(1981) - et al.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
(1951) - et al.
Enhancement of morphine an algesia by tricyclic antidepressants
Neuropharmacology
(1979) - et al.
Multiple opiate receptors: differential binding of μ, κ and α agonists
Neuropharmacol.
(1981) Poisoning by tricyclic antidepressant drugs: general and pharmacokinetic considerations
Int. J. Clin. Pharmacol.
(1975)- et al.
The total fate of a drug: kinetics of distribution, excretion and formation of 14 metabolites in rats treated with imipramine
Arch. Int. Pharmacodyn
(1968)
Studies on the potentiation of the antinociceptive effect of oxotremorine by tetrabenazine in mice
Psychopharmacologia (Berlin)
Naloxone, naltrexone, and related noroxymorphones
Adv. Biochem. Psychopharmacol.
Effect of antimitotic agents on morphine induced analgesia
Alteration in brain receptors in affective disorders
Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness
Drugs
Nomifensine: a review of its pharmacological properties and therapeutic efficacy in depressive illness
Drugs
Effects of thymoleptics on hippocampus electrical reactivity and on rhinencephalic behavior reactions to pain
Morphine pellet implantation in rats: quantitative assessment of tolerance and dependence
J. Pharmacol. Exp. Ther.
Cited by (85)
Mechanisms of morphine-venlafaxine interactions in diabetic neuropathic pain model
2015, Pharmacological ReportsEffect of amitriptyline on glycinergic transmission in rat medullary dorsal horn neurons
2012, Brain ResearchCitation Excerpt :For example, amitriptyline blocks various subtypes of VDNCs, including TTX-sensitive and TTX-resistant Na+ channels, in a state-dependent manner in sensory neurons (Bräu et al., 2001; Dick et al., 2007; Hur et al., 2008). Other mechanisms might include the inhibition of norepinephrine and/or serotonin reuptake in the spinal dorsal horn (Taiwo et al., 1985), the inhibition of various ligand-gated ion channels, such as nicotinic acetylcholine receptors (Freysoldt et al., 2009), NMDA receptors (Reynolds and Miller, 1988), P2X receptors (Nagata et al., 2009; but see also Sim and North, 2010), and the direct and indirect effects on μ-opioid receptors (Hamon et al., 1987; Isenberg and Cicero, 1984). In the present study, we found that amitriptyline at ≥ 10 μM concentrations significantly enhanced spontaneous glycine release onto medullary dorsal horn neurons.
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation
2011, Pharmacological ResearchCitation Excerpt :Although this study cannot rule out the influence of other neurotransmitters mediating MAE, such as noradrenaline or dopamine, which can also be stimulated by morphine [29,31] and regulated by 5-HT [32,33], there is good evidence that kappa receptors play a crucial role in nociception. This action could be mu-opioid receptor independent [8–34] and related to 5-HT modulation [35,36]. Our results point at new potential therapeutic applications of kappa-opioid receptor ligands and encourage new efforts in the development of ligands for these receptors as potential analgesics [37,38].
Antidepressants
2009, Current Therapy in PainAntidepressants
2008, Current Therapy in Pain: Expert ConsultEffects of chronic desipramine treatment on α<inf>2</inf>-adrenoceptors and μ-opioid receptors in the guinea pig cortex and hippocampus
2008, European Journal of Pharmacology