Regular paperEffects of antidepressant drugs on different receptors in the brain
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Compound action potential inhibition produced by various antidepressants in the frog sciatic nerve
2018, European Journal of PharmacologyCitation Excerpt :The adjuvants inhibit the pain through various mechanisms. For example, mechanisms for the antinociception produced by antidepressants are (1) activation of the noradrenaline- and serotonin-containing descending antinociceptive pathway to spinal dorsal horn by inhibiting the reuptake of their neurotransmitters (Ardid et al., 1995; Max et al., 1992), (2) involvement of α adrenoceptors, H1-histamine, serotonin, opioid and muscarinic acetylcholine receptors (Anjaneyulu and Chopra, 2006; Cervantes-Durán et al., 2013; Ghelardini et al., 2000; Hall and Ögren, 1981; O’Donnell and Shelton, 2011; Sindrup et al., 2005; Wong and Bymaster, 2002) and (3) inhibition of voltage-gated Na+ (Dick et al., 2007; Ishii and Sumi, 1992; Le Cudennec and Castagné, 2014; Leffler et al., 2007; Nicholson et al., 2002; Pancrazio et al., 1998; Song et al., 2000; Stoetzer et al., 2016; Wang et al., 2004, 2010; Yan et al., 2010), Ca2+ (Traboulsie et al., 2006; Wu et al., 2012), NMDA-receptor (Reynolds and Miller, 1988; Sernagor et al., 1989; Watanabe et al., 1993) and P2X4-receptor channels (Nagata et al., 2009). The Na+-channel inhibition is mimicked by antiepileptics, α2-adrenoceptor agonists and local anesthetics, and therefore is one of mechanisms for antinociception produced by the other adjuvants.
Learning from the past and looking to the future: Emerging perspectives for improving the treatment of psychiatric disorders
2015, European NeuropsychopharmacologyCitation Excerpt :Clomipramine (FDA approved, 1964) was found to be more selective in blocking 5-HT re-uptake compared to previously-launched TCAs (Carlsson et al., 1969; Millan et al., 2001). Interestingly, clomipramine is also effective in the treatment of panic disorder and especially obsessive compulsive disorder (OCD), by a mechanism poorly understood even today (Fineberg and Gale, 2005; Hall and Ogren, 1981; Pizarro et al., 2014). The above-mentioned premise that an elevation in 5-HT availability enhances mood set the stage for the intensive search for 5-HT selective reuptake inhibitors (SSRIs) in the 1970s and 1980s by almost every major pharmaceutical firm worldwide (Block and Nemeroff, 2014; Connolly and Thase, 2012; Healy, 1997).
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain
2014, Pharmacological ReportsCitation Excerpt :A question regarding the involvement of the opioid system after local administration of antidepressants still remains unclear. Initial investigations suggested that tricyclic antidepressants have a low affinity to opioid receptors [55]. Venlafaxine has been characterized as being able to act on the opioid system and enhance opioid analgesia when administered with a selective opioid agonist, and this action is inhibited by selective opioid antagonists. [56].
Novel drug OMS103HP reduces pain and improves joint motion and function for 90 days after arthroscopic meniscectomy
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