Tachyphylaxis to β-adrenoceptor agonists in guinea pig airway smooth muscle in vivo and in vitro☆,☆☆
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2007, Current Topics in Developmental BiologyCitation Excerpt :Airway smooth muscle (ASM) acts as the primary effector cell regulating bronchomotor tone. Early studies of β‐adrenergic agonists discovered that short‐term (20 min) incubation of guinea pig tracheas with catecholamines stimulated cAMP production leading to ASM cell relaxation (Douglas et al., 1977). Pharmacological inhibition of PDEs with the nonselective PDE inhibitor, theophylline, further demonstrated that augmentation of cAMP levels evokes ASM relaxation (Newman et al., 1978; Polson et al., 1978; Triner et al., 1977).
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Supported in part by USPHS grants HL-14534 and HL-14179 from the National Heart and Lung Institute.
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A preliminary report of this work has been presented (The Physiologist, 15: 197, 1975).
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Present address: Department of Pharmacology, Organon Laboratories, Ltd., Newhouse, Lanarkshire, Scotland.