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Behavioral and neurochemical responses derived from dopaminergic intrastriatal grafts in hemiparkinsonian rats engaged in a novel motor task
2018, Journal of Neuroscience MethodsCitation Excerpt :Apomorphine is a direct agonist with efficacy on either dopamine D1- or D2-like DA receptors in the striatum, where plastic adaptations render these receptors more responsive following DA-depleting lesions. As such, apomorphine doses typically require development of DA receptor supersensitivity, a common postsynaptic compensatory response that requires some time to develop following DA-depleting lesions in order to generate significant rotation (Marshall and Ungerstedt, 1977). This supersensitivity takes up to a week to develop in the lesioned hemisphere, rendering apomorphine a less popular way of assessing lesions (Schwarting and Huston, 1996).
Excess amounts of 3-iodo-L-tyrosine induce Parkinson-like features in experimental approaches of Parkinsonism
2018, NeuroToxicologyCitation Excerpt :Apomorphine induces contralateral turning (away from the lesioned hemisphere) as a result of postsynaptic dopamine receptor super-sensitivity (Marshall and Ungerstedt, 1977; Sauer and Oertel, 1994; Schwarting and Huston, 1996a; Heuer et al., 2012). The postsynaptic dopamine receptor super-sensitivity is more related to the extent of dopamine depletion than amphetamine-induced turning response (Marshall and Ungerstedt, 1977). Behavioral data were analyzed with MiniTab16 software package for statistical analysis (AddLink, Spain).
Rapid facilitation of ultrasound production and lordosis in female hamsters by horizontal cuts between the septum and preoptic area
2014, Physiology and BehaviorCitation Excerpt :The same may well apply to ARD's companion effect on ultrasound production. However, the present results suggest that these changes develop more gradually than those in lordosis, allowing for the possibility that denervation supersensitivity accounts for at least the changes that occurred relatively late, beyond the first 2 days postop [17,27,32,34]. Therefore, the analysis of the mechanism underlying ARD's effects on ultrasound production may require further work tailored to the major alternatives.
Chapter 4 Molecular Aspects of Neurotoxins in Dopaminergic Neurons
2009, Advances in Molecular ToxicologyCitation Excerpt :6-Hydroxydopamine was the first highly selective neurotoxin for catecholaminergic neurons, and its selectivity of action was dependent on the fact that 6-hydroxydopamine has high affinity for the norepinephrine and DAT [2]. Unilateral 6-hydroxydopamine-lesioned rats circle in the direction of the lesion, while dopamine agonists produce contralateral turning—due to the development of D2 receptor super sensitization on the lessened side [3–7]. The neurotoxin 6-hydroxydopamine has been a valuable tool used to investigate motor and biochemical dysfunctions in PD [8–11].