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3H-spiroperidol labels dopamine receptors in pituitary and brain

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Abstract

3H-Spiroperidol of high specific radioactivity labels dopamine receptors in membranes of bovine caudate nucleuse an anteroir pituitary. The saturation and kinetic properties of 3H-spiroperidol binding are similar in the two tissues. In both caudate and pituitary 3H-spiroperidol displays very high affinity with a dissociation constant of 0.2–0.3 nM. The relative potencies of numerous dopamine agonist and antagonists in competing for 3H-spiroperidol binding are closely similar in anterior pituitary and caudate.

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