Preliminary report on a case of apolipoproteins CI and CII deficiency

doi:10.1016/0009-8981(86)90299-8

Clinica Chimica Acta

Volume 157, Issue 3, 30 June 1986, Pages 239-248

https://doi.org/10.1016/0009-8981(86)90299-8 Get rights and content

Abstract

A combined deficiency of Apo C-I and C-II assessed by mono and bidimensional electrophoresis as well as immunoelectrophoresis is described. It was discovered after a ‘check up’ in a 70-yr-old woman consulting for a vertebral pain. Lipoprotein disorders correspond to a particular form of Fredrickson's type V. They consisted of types I and IV, with decreased HDL of low electrophoretic mobility, increased VLDL of high electrophoretic mobility, and without LDL. A decrease of Apo A-I, A-II, B and C-III was observed. Data correspond for the most part with all those actually known to characterize Apo C-II deficiency. HDL₃ predominance in decreased HDL fraction and strongly decreased CE/TC ratio could be dependent of Apo C-I deficiency. The association of these two apolipoprotein deficiencies, the genes of which are located on chromosome 19, suggest a common defect on the pathway of their biosynthesis possibly located at the gene level. In spite of these numerous anomalies, the affection appears well tolerated.

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Preliminary report on a case of apolipoproteins CI and CII deficiency

Abstract

Atherosclerosis

Lancet

Metabolism

Clin Chim Acta

Atherosclerosis

Clin Chim Acta

Clin Chim Acta

Analyt Biochem

Analyt Biochem

J Biol Chem

Analyt Biochem

J Lipid Res

Atherosclerosis

Hypertriglyceridemia associated with deficiency of apolipoprotein C II

N Engl J Med

Inheritance of apolipoprotein C II deficiency with hypertriglyceridemia and pancreatitis

N Engl J Med

Familial apolipoprotein C II deficiency plasma-lipoproteins and apolipoproteins in heterozygous and homozygous subjects and the effects of plasma infusion

Eur J Clin Invest