Myeloperoxidase catalysed cooxidative metabolism of methimazole: Oxidation of glutathione and NADH by free radical intermediates
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Oxidation of anti-thyroid drugs and their selenium analogs by ABTS radical cation
2023, Bioorganic ChemistryThyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways
2012, Toxicology and Applied PharmacologyCitation Excerpt :MMI and PTU are typically used to treat hyperthyroidism, including Graves’ disease, resulting in returning thyroid function to within normal range (Abuid and Larsen, 1974; Nakamura et al., 2007; Roy and Mugesh, 2005; http://www.medicinenet.com/ methimazole/article.htm). Inhibition of TPO by MMI and PTU is mainly via the interaction of the thione group of these compounds with the metal center of TPO, comprising an iron-sulfur coordination which is common with metalloenzymes (McGirr et al., 1990; O'Brien, 2000; Tafazoli and O'Brien, 2005). These drugs may also trap iodine through the formation of stable donor-acceptor electron complexes with diiodine, depleting iodine for the iodination of thyroglobulin (Tg) (Brock and Head, 1966; Marchant et al., 1971, 1972; Raby et al., 1990; Roy and Mugesh, 2006; Wartofsky and Ingbar, 1971).
Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues
2010, Toxicology and Applied PharmacologyGlutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity
2007, Free Radical Biology and MedicinePeroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH
2004, Chemico-Biological InteractionsCitation Excerpt :The biological activity of these drugs depends on the physicochemical properties of the drug, the type of target tissue acted on, and the presence of functional groups on the phenothiazine lead structure [4]. Previously, we showed that the sulfur radical of methimazole (methimazole thiyl radical) formed by myeloperoxidase or horseradish peroxidase co-oxidised glutathione and NADH to form reactive oxygen species [5]. The methimazole thiyl radical was implicated in the inactivation of thyroid peroxidase, possibly explaining the therapeutic usefulness of this compound for treating hyperthyroidism [6].
Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: Glutathione oxidation and conjugation
2001, Free Radical Biology and Medicine