Transforming growth factor-β1 promotes re-elongation of injured axons of cultured rat hippocampal neurons

doi:10.1016/0006-8993(96)00253-3

Brain Research

Volume 723, Issues 1–2, 3 June 1996, Pages 206-209

https://doi.org/10.1016/0006-8993(96)00253-3 Get rights and content

Abstract

Transforming growth factor-β1 (TGF-β1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-β1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-β1 on neurite regeneration following axotomy was investigated. The axonal growth was stopped by laser irradiation, but addition of TGF-β1 remarkably promoted the axonal re-elongation from the injured site. The effect of TGF-β1 was concentration dependent and seen maximally at a concentration of 1 ng/ml. These results suggest that TGF-β1 has a capability of promoting axonal regeneration of brain neurons after lesioning.

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Transforming growth factor-β1 promotes re-elongation of injured axons of cultured rat hippocampal neurons

Abstract

Jpn. J. Pharmacol.

J. Biol. Chem.

Brain Res.

Brain Res.

Mol. Brain Res.

Trends Pharmacol. Sci.

Brain Res.

Neurosci. Lett.

Kidney Int.

Brain Res.

Growth factors from murine sarcoma virus-transformed cells

The establishment of polarity by hippocampal neurons in culture

J. Neurosci.