The role of GABAA receptors in the subsensitivity of Purkinje neurons to GABA in genetic epilepsy prone rats
Referencess (30)
- et al.
Soluble gamma-aminobutyric acid and benzodiazepine receptors from rat cerebral cortex
Life Sci.
(1981) - et al.
Kainic acid differeniates GABA receptors from benzodiazepine receptors in rat cerebellum
Brain Res.
(1980) Electrophysiology of GABAA and GABAB receptor subtypes
Trends Neurosci.
(1988)- et al.
GABAA and GABAB receptor distribution in the rat central nervous system
Neuroscience
(1987) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Anal. Chem.
(1976)Microelectrophoresis
- et al.
Decreased effectiveness of GABA-mediated inhibition in the inferior colliculus of the genetically epilepsy-prone rat
Exp. Neurol.
(1986) - et al.
Inferior colliculus neuronal response abnormalities in genetically epilepsy-prone rats: evidence for a deficit of inhibition
Life Sci.
(1986) Roles of neurotransmitter amino acids in seizure severity and experience in genetically epilepsy-prone rat
Brain Res.
(1991)- et al.
Biophysical and pharmacological properties of cloned GABAA receptor subunits expressed in Xenopus oocytes
Neuron
(1988)
Responses of cerebellar Purkinje cells to mossy fiber activation
Brain Res.
Potentiation of gamma-aminobutyric acid-mediated inhibition by isoproterenol in the cerebellar cortex: receptor specificity
Neuropharmacology
The GABAA receptor-gated ion channel: biochemical and pharmacological studies of structure and function
Biochem. Pharmacol.
The effect of γ-amino-butyric acid on3H-flunitrazepam binding in rat brain
Eur. J. Pharmacol.
VI. Electrophysiological assessment of monoamine synaptic function in neuronal circuits of seizure susceptible brains
Life Sci.
Cited by (19)
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures
2021, Neurobiology of DiseaseCitation Excerpt :Images were quantified using AzureSpot 2.0 software (Azure Biosystems, Sierra Court, CA, USA). Membranes were isolated as described previously (Gould et al., 1995). Membrane fraction aliquots were thawed and diluted with 50 mM TRIS-citrate (pH = 7.1, +4 °C).
Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR)
2018, Neurobiology of DiseaseCitation Excerpt :GEPR-3 display increased NE content in the cerebellum, but decreased norepinephrine (NE) content in other brain regions (Jobe et al., 1982) and lower serotonin in cerebellum as compared to either control SD rats or GEPR-9 (Dailey et al., 1992). Moreover, both GEPR-3 and GEPR-9 display reduced sensitivity to GABAergic inhibition within the cerebellum (Gould et al., 1995; Molnar et al., 2000). While equivalent studies have not been performed in WAR, our imaging findings underscore the importance of examining this further.
Genetic Models of Reflex Epilepsy and SUDEP in Rats and Mice
2017, Models of Seizures and Epilepsy: Second EditionNeuronal Networks in Epilepsy: Comparative Audiogenic Seizure Networks
2014, Neuronal Networks in Brain Function, CNS Disorders, and TherapeuticsKetogenic diet, brain glutamate metabolism and seizure control
2004, Prostaglandins Leukotrienes and Essential Fatty Acids