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An update on the connections of the ventral mesencephalic dopaminergic complex
2014, NeuroscienceCitation Excerpt :A variety of morphological, electrophysiological and molecular biological characteristics of VTA DA neurons vary with their projection targets. Earlier studies showed that DA neurons in the medial part of the VTA projecting to medial Acb are smaller and have fewer and shorter dendritic branches as compared to lateral VTA neurons projecting to more lateral parts of the Acb (Tan et al., 1995). Lammel et al. (2008) extended these findings in a recent study that employed experimental neuroanatomical, electrophysiological, immunohistochemical and laser-dissection techniques to demonstrate one group of neurons centered in the medial VTA that projects to the mPfC, Acb medial shell and core, and basolateral amygdala and another positioned mainly in the lateral VTA that projects to the Acb lateral shell and ventrolateral CPu.
Vulnerabilities of ventral mesencephalic neurons projecting to the nucleus accumbens following infusions of 6-hydroxydopamine into the medial forebrain bundle in the rat
2004, Brain ResearchCitation Excerpt :Approximately spherical FG injection sites with diameters between 650 and 1000 μm resulted from the injection parameters utilized (Figs. 1B and 2B, D, F and H). The injections were quite similar to those generated in previous studies from this lab [2,43,45]. Only cases with injections that were localized predominantly, if not quite exclusively, in the medial half of the shell (Figs. 1A and 2B and D) or the core (Fig. 2F and H) were evaluated further.
Autoregulation of dopamine synthesis in subregions of the rat nucleus accumbens
2001, European Journal of PharmacologyCatecholamine systems in the brain of vertebrates: New perspectives through a comparative approach
2000, Brain Research ReviewsCitation Excerpt :In turtles, PNMTi cell bodies lie in locations that correspond to those found for the C1 and C2 adrenergic cell groups of mammals, but, in a gekkonid lizard, only a C1 group is recognized [656,661]. Because of their involvement in neurological diseases such as Parkinson’s disease, the organization and connections of the mammalian midbrain A8–A10 CA cell groups, and particularly their mesostriatal projections, have been extensively studied [230,331,411,412,569,570,711]. Although the DA cells of the A8–A10 groups form a continuum without clear boundaries between groups, experimental hodological studies have shown that the ascending midbrain projections are topographically organized.
On the altered expression of tyrosine hydroxylase and calbindin-D 28kD immunoreactivities and viability of neurons in the ventral tegmental area of Tsai following injections of 6-hydroxydopamine in the medial forebrain bundle in the rat
2000, Brain ResearchCitation Excerpt :This suggests, but does not prove, that VTA neurons that give rise to the core innervation, of which many express CB-ir [37], were preferentially caused to degenerate by the lesions. The actual relative losses of accumbens core vs. shell CB-ir neuron profiles remain to be addressed empirically by labeling ventral mesencephalic neurons with a retrogradely transported marker following placement in the core and shell of the nucleus accumbens [2,36,37] in rats that also get injections of 6-OHDA into the medial forebrain bundle. Nevertheless, it is conditionally concluded that CB-ir is expressed by a subset of TH-ir VTA neurons that is at least as vulnerable to 6-OHDA as TH-ir neurons lacking CB.