In vivo imaging of brain incorporation of fatty acids and of 2-deoxy-d-glucose demonstrates functional and structural neuroplastic effects of chronic unilateral visual deprivation in rats
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Cited by (16)
Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid
2016, Prostaglandins Leukotrienes and Essential Fatty AcidsCitation Excerpt :Brain membrane phospholipids are highly enriched with the polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (AA, 20:4n-6), which participate in neurotransmission [1,2], gene transcription and the regulation of brain immunity [3–5].
Imaging Brain DHA Metabolism in Vivo, in Animals, and Humans
2014, Omega-3 Fatty Acids in Brain and Neurological HealthImaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans
2012, Brain Research BulletinCitation Excerpt :These findings agreed with our demonstrating an age-invariance of PVC-corrected rCMRglc in healthy men [115]. We used our published visual test–retest paradigm [171], and the fact that we reported regional increments in k* for AA following visual activation [264] to image rCBF and brain AA incorporation in healthy subjects exposed to visual flash stimulation at 2.9 or 7.8 Hz and a dark (0 Hz) condition in the same PET session. We injected [15O]H2O and [1-11C]AA in each of the two conditions, and developed equations to take into account radioactive half-lives.
Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission
2011, Prostaglandins and Other Lipid MediatorsCitation Excerpt :One approach that as has not been exploited sufficiently is the use of radiolabeled DHA to image its role in regional brain signal transduction and neuroplasticity with quantitative autoradiography in vivo. For example, 3 months after removing one eye in a rat, DHA incorporation from plasma into contralateral brain regions, e.g. superficial gray matter of the superior colliculus and dorsal lateral geniculate nucleus, that normally received input from the eye that was removed, was significantly reduced, emphasizing a role for DHA in signaling and neuroplasticity that deserves to be exploited [33]. DHA incorporation also was altered in an L1210 leukemia cells implanted in rat brain, suggesting a role for DHA in tumor metabolism [34].
Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography
2009, Journal of Lipid ResearchCitation Excerpt :In the adult human, newly formed neurons (and perhaps synapses also) may help to shape existing neural circuitry and thereby permit rapid changes in neuropsychiatric function in response to dietary change (53, 54). When injected, [1-11C]DHA was taken up to a greater extent in gray than white matter and varied 2-fold in gray matter regions, consistent with previous studies in rats (19, 20) (Table 1). High uptake into the neocortex is consistent with evidence that incorporation of DHA occurs into phospholipids of brain synaptic membranes (21), that DHA is enriched in aminophospholipids of gray matter (55, 56), and that high levels of DHA are found in gray matter (57).
- 1
Present Address: Department of Neurosurgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113, Japan.
- 2
Food and Drug Administration/CDER, HFD-120, 5600 Fishers Lane, Rockville, MD 20857, USA.