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Opioid addiction and the cerebellum
2019, Neuroscience and Biobehavioral ReviewsRole of orexin type-1 receptors in paragiganto-coerulear modulation of opioid withdrawal and tolerance: A site specific focus
2017, NeuropharmacologyCitation Excerpt :This is revealed by enhancement of LC firing rate following injection of opioid-receptor antagonists in opiate dependent animals (Aghajanian, 1978; Rasmussen and Aghajanian, 1989; Valentino and Wehby, 1989). In this regard, it is noteworthy that the LC is the most sensitive brain structure for local induction of opiate withdrawal (Maldonado et al., 1992), and destruction (Maldonado and Koob, 1993) or pharmacological inhibition of this brain region (Taylor et al., 1988) significantly attenuates the severity of withdrawal signs. In 1990, Rasmussen et al., reported that the expression of morphine withdrawal signs occurs temporally in parallel with the increased activity of LC neurons (Rasmussen et al., 1990).
Intracoerulear microinjection of orexin-A induces morphine withdrawal-like signs in rats
2017, Brain Research Bulletin
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Present address: Unité de Pharmacochimie Moléculaire, INSERM U 266, Faculté de Pharmacie, Paris, France.