High d-glucose concentrations increase GABA release but inhibit release of norepinephrine and 5-hydroxytryptamine in rat cerebral cortex
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Zero net flux estimates of septal extracellular glucose levels and the effects of glucose on septal extracellular GABA levels
2009, European Journal of PharmacologyHippocampal infusions of glucose reverse memory deficits produced by co-infusions of a GABA receptor agonist
2008, Neurobiology of Learning and MemorySeptal co-infusions of glucose with a GABA<inf>B</inf> agonist impair memory
2006, Neurobiology of Learning and MemoryHippocampal infusions of pyruvate reverse the memory-impairing effects of septal muscimol infusions
2005, European Journal of PharmacologyCitation Excerpt :These studies show that glucose exacerbates memory deficits produced by muscimol or interact with sub-effective doses of muscimol to produce a deficit. Consistent with the idea that glucose may impair memory by increasing GABA activity, evidence indicates that acute administration of large amounts of glucose and experimentally induced hyperglycemia increase GABA levels in the brain (Amoroso et al., 1990; During et al., 1995; Fink and Gothert, 1993; Fink et al., 1994; Ohtani et al., 1997). Elevated glucose levels may impair memory through a process that involves glycolytic metabolism.
Septal infusions of glucose or pyruvate, but not fructose, produce avoidance deficits when co-infused with the GABA agonist muscimol
2003, Neurobiology of Learning and Memory
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