Elsevier

Brain Research

Volume 587, Issue 1, 31 July 1992, Pages 95-101
Brain Research

Research report
Acetylcholine modulates averaged sensory evoked responses and perforant path evoked field potentials in the rat dentate gyrus

https://doi.org/10.1016/0006-8993(92)91432-EGet rights and content

Abstract

The effect of localized application of acetylcholine (ACh) on well chacracterized components of sensory evoked and electrically induced potentials in the dentate gyrus was investigated in rats while performing a tone discrimination task. Local pressure application of ACh to the granule cell layer of the dentate gyrus through the recording pipette increased the amoplitude of perforant path evoked population spikes without changing the amplitude of the field EPSP. When the pipette was relocated to the outer molecular layer of the dentate (OM), ACh application decreased the amplitude of the perforant path field EPSP. Two major components of the averaged auditory evoked potential (AEP) recorded during criterion performance of the discrimination task were significantly changed by dendritic application of ACh. The N1 component of the OM AEP which has been shown to reflect perforant path synaptic activity decreased in amplitude while the N2 component wich represent activity from septal connections, was significantly increased. These effects were not due to pressure ejection nor drug related changes in behavioral performance of the task. The results suggest that ACh may act to differentially modulate the synaptic excitability of dentate granule cells, allowing them to acquire responses to sensory stimulation during establishment and maintenance of discrimination learning.

References (30)

Cited by (33)

  • Activation of dominant hemisphere association cortex during naming as a function of cognitive performance in mild traumatic brain injury: Insights into mechanisms of lexical access

    2017, NeuroImage: Clinical
    Citation Excerpt :

    The findings of a pair of in vitro and in silico studies indicate that top-down control enhances the expression of stimulus generated transient local gamma frequency activity (attractor states) in supragranular layers, but only in the presence of cholinergic modulation, increasing neuronal activation (Roopun et al., 2010; Lee et al., 2015). Additionally, Ach exhibits direct effects on the amplitude of evoked/event related responses, generally facilitating an increase in amplitude at physiological levels, especially when baseline amplitudes are relatively low (Wang et al., 1999; Knot et al., 2014; Foster and Deadwyler, 1992). Cholinergic systems can be damaged as a result of TBI (Shin and Dixon, 2015) and the premorbid/developmental or post-concussive status of Ach system function could have a substantial impact on the overall magnitude of early task-related activation of neocortex as well as on the appropriate activation and suppression of specific linguistic representations during lexical access.

  • Long-term ginsenoside administration prevents memory loss in aged female C57BL/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus

    2011, Neuroscience
    Citation Excerpt :

    Additionally, estrogen enhances LTP in the hippocampus, which is a postulated model for the synaptic changes that may underlie learning and memory (Adams et al., 2001; Brann et al., 2007). In addition, Tom C. Foster et al. have reported the changes of acetylcholine, intrastriatal D2 receptor, and immediate early gene expressions in aged mice (Foster and Deadwyler, 1992; Mennicken et al., 1995; Abrous et al., 1996). In order to thoroughly understand the beneficial effect of ginsenoside on learning and memory, it would be necessary in future research to show the effect of ginsenoside on the estrous cycle of mice and to record the total distance or movement speeds in open-field test to exclude the effect of ginsenoside on the locomotor ability.

View all citing articles on Scopus
View full text