Histamine-caused itch induces Fos-like immunoreactivity in dorsal horn neurons: effect of morphine pretreatment
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Cited by (32)
Role of kainate receptors in pruriceptive processing in the mouse spinal cord
2023, European Journal of PharmacologyInhibitory effects of antibiotic-induced gut microbiota depletion on acute itch behavior in mice
2022, Brain Research BulletinCitation Excerpt :Itch sensation can be elicited by the activation of sensory neurons whose cell bodies are located in the dorsal root ganglion (DRG) or TG. Itch-sensitive neurons are activated by a variety of pruritogens, which is evidenced by inducing the expression of the c-Fos protein (Presley et al., 1990; Yao et al., 1992). According to previous reports, pruritogens including compound 48/80, CQ, and 5-HT can induce the expression of c-Fos in spinal cord dorsal horn neurons (Funahashi et al., 2014; Pandey et al., 2017).
BOLD responses to itch in the human spinal cord
2015, NeuroImageCitation Excerpt :They are narrowly tuned to histamine, have large innervation territories and very low conduction velocities (Schmelz et al., 1997). Andrew and Craig (2001) exploited this characteristic profile to localize the associated projection neurons in the cat spinal cord, which were detected in lamina I. Another study on Fos-like immunoreactivity discovered elevated expression in laminae I and II after histamine treatment (Yao et al., 1992). The response described in our study is located in the dorsal portion of the ipsilateral spinal cord and thus fits to these previous findings.
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord
2014, NeuroscienceCitation Excerpt :Itch is described as an irritating sensation that triggers a desire to scratch, and SP-induced scratching was attenuated by the administration of NK1 receptor antagonists, suggesting that SP and the NK1 receptor may be involved not only in nociceptive processing, but also in pruriceptive processing (Kuraishi et al., 1995; Carstens et al., 2010). An intradermal injection of histamine and serotonin (5-HT, 5-hydroxytriptamine), which are well-known pruritic agents, induced scratching behavior (Yamaguchi et al., 1999; Nojima and Carstens, 2003; Shimada and LaMotte, 2008; Sun et al., 2009; LaMotte et al., 2011) and also enhanced c-Fos expression in the spinal dorsal horn (Yao et al., 1992; Nojima et al., 2003; Nakano et al., 2008). These findings indicated that the induction of scratching behavior and enhancement of c-Fos expression in the spinal cord following the administration of pruritic agents may be valuable tools for identifying pruriceptive processing at the level of the spinal cord.
Neuronal conditions of spinal cord in dermatitis are improved by olopatadine
2006, European Journal of PharmacologyFos, nociception and the dorsal horn
2005, Progress in Neurobiology
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Present address: Department of Anatomy, Wakayama Medical School, 27 Kyuban-cho, Wakayama City, Wakayama 640, Japan.