Research reportDevelopmental expression, compartmentalization, and possible role in excitotoxicity of a putative NMDA receptor protein in cultured hippocampal neurons
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2013, American Journal of PathologyBlockers of adenosine A1, but not muscarinic acetylcholine, receptors improve excessive extracellular glutamate-induced synaptic depression
2013, Neuroscience ResearchCitation Excerpt :Co-application of AP-5 similarly increased the recoveries in PSs and fEPSPs after the washout, indicating that NMDA-type glutamate receptors contribute to the excessive glutamate-induced excitatory synaptic depression but do not significantly work to depress somatic excitability. Selective depression of dendritic excitatory synaptic transmissions without that of somatic excitability, mediated by NMDA-type glutamate receptors localizing on both dendrites and a soma in a hippocampal pyramidal neuron (Mattson et al., 1991), is a novel finding, which can be observed by simultaneous PS and fEPSP recordings with the MEA system. Immediate recovery of edrophonium-induced fEPSP depression after its washout and lack of an effect of edrophonium on PSs indicate that its ChE inhibiting action does not remain after the washout, at which time excessive glutamate-induced synaptic change was evaluated in the present study.
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2010, Neurochemistry InternationalSelective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-d-asparate-type glutamate receptors
2010, NeuroscienceCitation Excerpt :However, significant methodological differences between these studies are apparent, most notably, the age of tissue in vitro (5 vs. 10 days in vitro, after Mulholland and Prendergast, 2003 and Ikegaya and Matsuki, 2002, respectively). Previous work employing dissociated hippocampi has demonstrated that in vitro aging (as early as 0–8 days in culture) is associated with increased sensitivity of hippocampal pyramidal cells to NMDA-induced excitability (Mattson et al., 1991). Thus, the differences described above with regard to the necessity of tri-synaptic hippocampal circuitry for the expression of CA1 pyramidal cell injury may be related to the in vitro aging.
Immediate neuronal preconditioning by NS1619
2009, Brain ResearchCitation Excerpt :Positive immunostaining for microtubule-associated protein-2 and negative immunostaining for glial fibrillary acidic protein verified that the cultures were composed of more than 98% of neurons on day 7 in vitro. Experiments were carried out on 7–9-day old cultures, during which period neurons expressed NMDA, α-amino-3-hydroxy-5-methylisoxazole-4-propionate, and kainate receptors and were vulnerable to glucose deprivation (Mattson et al., 1991, 1993). For medium changes, fresh FM was used in all experiments.
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2009, Brain ResearchCitation Excerpt :Positive immunostaining for microtubule-associated protein-2 and negative immunostaining for glial fibrillary acidic protein verified that the cultures were composed of more than 98% of neurons on day 7 in vitro (DIV 7). Experiments were carried out on 7–9 day old cultures, during which neurons expressed N-methyl-d-aspartate, α-amino-3-hydroxy-5-methylisoxazole-4-propionate, and kainate receptors and were vulnerable to glucose deprivation (Mattson et al., 1991, 1993). Adenoviral vectors were stored in 3% sucrose/phosphate buffered saline (PBS) at − 80 °C.