Autoradiographic distribution of μ, δ and κ opioid binding sites in the superficial dorsal horn, over the rostrocaudal axis of the rat spinal cord
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Intrathecal fentanyl blockade of afferent neural feedback from skeletal muscle during exercise in heart failure patients: Influence on circulatory power and pulmonary vascular capacitance
2015, International Journal of CardiologyCitation Excerpt :Assessment of the influence of feedback from group III/IV nerve fibers during exercise in humans remains challenging. However, μ-opioid receptors which can be found superficially located on the lumbar dorsal horn of the spinal cord where group III/IV nerve fibers synapse represent a feasible target for pharmacological manipulation of afferent neural signaling [21–24]. The selective μ-opioid receptor agonist has been shown to inhibit the cortical projection of group III/IV neural feedback in human and animal models [16,21,25].
Opioid administration following spinal cord injury: Implications for pain and locomotor recovery
2013, Experimental NeurologyCitation Excerpt :How locomotor function and pain are affected by opioids following SCI, however, has yet to be fully examined. Three classic opioid receptors, the μ-opioid receptor (MOR), δ-opioid receptor (DOR), and κ-opioid receptor (KOR) have been identified and are located throughout regions of the brain, brainstem, spinal cord, and periphery on both presynaptic (e.g. afferent fibers), postsynaptic (e.g. dorsal horn neurons), and glial cells (Arvidsson et al., 1995; Atweh and Kuhar, 1977a, 1977b, 1977c; Besse et al., 1990a, 1990b, 1991; Fields et al., 1980; Mansour et al., 1987; Pert and Snyder, 1973a, 1973b; Pert et al., 1973; Simon, 1973; Terenius, 1973; Yaksh, 1997; reviewed by Hutchinson et al., 2011; Stein et al., 1989; Yaksh and Noueihed, 1985). Traditionally, opioid receptor agonists are known for their analgesic (antinociceptive) and rewarding, hedonic properties.
Spinal motor actions of the μ-opioid receptor agonist DAMGO in the cat
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